advertisement
Home » Drugs » Trintellix

Trintellix

Generic Name: Vortioxetine (formerly known as Brintellix)

Drug Class: SSRI

Table of Contents

Trintellix

 

 

 

 

Overview

Trintellix (Vortioxetine) is an antidepressant used to treat depression / major depressive disorder in adults. It works by helping to restore the balance of serotonin in the brain. This medication is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator.

Taking this medication may improve your interest in daily living. It may also help stabilize your sleep patterns, mood, appetite, and increase your energy.

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.


How to Take It

Take this medicine as directed. It can be taken with or without food. Do not stop taking this medicine abruptly without consulting with your doctor.

Side Effects

Side effects that may occur while taking this medicine include:

  • passing gas
  • spinning sensation
  • dry mouth
  • change in taste
  • constipation
  • heartburn
  • decreased interest in sex
  • blurred vision

Contact your doctor if you experience symptoms that become bothersome, including:

  • agitation
  • increased thirst
  • black stools
  • breathing problems
  • vomiting blood
  • twitching muscles
  • seizures
  • poor coordination

Warnings & Precautions

  • DO NOT use this medication if you are being treated with linezolid or methylene blue injection.
  • Younger adults and teenagers may experience suicidal thoughts when starting this medication. Be sure to check in regularly with your doctor to monitor your progress.
  • Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant.
  • You may experience dizziness while taking this drug. DO NOT use any type of machinery, drive a vehicle, or perform activities that require alertness until you are confident you can do them safely.
  • Tell your doctor if you have trouble sleeping, anxiety, panic attacks, or are feeling restless, impulsive or irritable.
  • Tell your doctor if you have liver disease, low levels of sodium, if you take blood thinners (or aspirin), or have narrow angle glaucoma.
  • For an overdose, seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Before taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes supplements and herbal products.

Dosage & Missed Dose

Follow all directions exactly as prescribed by your doctor. Your dosage may occasionally be changed by your doctor to ensure the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

If you skip a dose, take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.

Pregnancy/Nursing

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is also not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website: https://www.nlm.nih.gov/medlineplus/druginfo/meds/a614003.html

 

Trintellix


Overall Review of this Medication

3.18/5 (14 votes)
1/1
2.43/5
3.07/5
3.64/5
3.21/5

21 thoughts on “Trintellix

  • May 9, 2017 at 11:45 pm
    Permalink

    I think I’ve tried every antidepressant made. A few have worked much better than others bit more compare to Trintellix. I haven’t had any negative side effects at all. I only wish this medication was affordable..

    4.05/5

    1/5

    5/5

    5/5

    5/5

    Reply
    • December 29, 2017 at 1:08 pm
      Permalink

      Ask dr for free samples! I first got diarrhea at 5 mg for a week then at 10 mg a week later I had to get off! Got real nauseous& took cola syrup still felt nauseous then threw up! Just another drug poison out there. Will continue counseling but won’t take a drug that also constipates! !!!

      2.14/5

      2/5

      2/5

      2/5

      2/5

      Reply
  • February 14, 2018 at 4:12 pm
    Permalink

    My son is 13years old , He was prescribed Trintellix 2 months ago.
    My son is High Functioning Autistic, ADHD, Tourettes Syndrome, and PTSD. We can see the how much this medicine has worked in him already!! I wish it wasn’t so expensive. Specially when our insurance wont cover it evan with the Doctor filling out paperwork! Etna is horrible for coving meds that work!!
    Our Son takes Trintellix and Abilify , 10mg each. I highly recommend this drug!!

    3.81/5

    1/5

    5/5

    4/5

    5/5

    Reply
  • July 7, 2018 at 2:14 pm
    Permalink

    In the 20 or so years that I have been treating my depression/anxiety/BPD/ADHD with medication, I have tried just about every drug on the market. I struggle with treatment resistance, and medications will often work for awhile and then become ineffective after a year or so. I have had periods of medication-induced-mania with other drugs such as Effexor of Zoloft, but have never had a medication-induced-mania as severe as I experienced with Trintellix. Be very careful taking this medication if you are on anything else that increases serotonin levels. I developed a severe allergic reaction and ended up being hospitalized due to the severity. I have never struggled with risk of suicide, and at age 30 I thought that the increased risk of suicidal thoughts and tenancies with this drug would not be as significant for someone out of their teens/early 20’s, but I had incredibly severe suicide ideation. I also developed symptoms of serotonin syndrome and hyponatremia, as well as an allergic reaction. I am on many other medications to deal with PCOS, and my doctor did not warn me of the adverse reactions that Trintellix can have when combined with medications for diabetes, medications that are classified as diuretics, and anti-nausea medications, all of which I am on. Trintellix can also have adverse reactions when combined with stimulants, such as adderall, which I take for ADHD, and anti-anxiety drugs, such as Xanax, which I also take. I assumed that my symptoms were from my drugs for PCOS, and dismissed them for several months, but they ended up so severe that I was taken to the hospital. Check very thoroughly if there are any possible drug interactions before taking Trintellix, because my doctor just glossed right over the fact that I may have interactions with this medication. My symptoms included severe vomiting and nausea, and I was prescribed Zofran, which interacts with Trintellix and can lead to serotonin syndrome. I experienced extreme muscle soreness and fatigue as well as swollen joints. My feet ached continuously and my hands, ankles, and face were swollen. I started having blurred vision, which is still subsiding, even after being off of the drug for a week. I developed a rash all over my face and redness around the eyes, which started going away a few days after being off Trintellix, but is still not completely gone. Trintellix made me have an erratic sleep schedule at best, and my manic symptoms were some of the most frightening things I have ever experienced. Please check with any medical professionals you may visit if you take medications for pain, anti-nausea medications, medications for diabetes or high blood pressure, any other medications for depression/anxiety, any drug that is classified as a ‘water pill’, and any drugs that act as stimulants, or if you consume a lot of caffeine. I do think that this could have been avoided if my psychiatrist was paying more attention to the other medications that my endocrinologist was prescribing for me. My reaction to Trintellix was much more extreme than most people’s, so it may end up being a drug that is worth considering for many people, but please be sure that any other medications and over-the-counter supplements you may take are put into consideration before you begin using this medication. Pricing should also be considered before using this drug. Without insurance, a 30 day supply will cost around $400, and many insurers will require you to try an exhaustive list of medications before they will cover this one. The makers of Trintellix do have a voucher that will enable you to get this medication for $10 a month for up to a year, but you are only eligible for that program if you already have insurance and if your insurance will cover Trintellix. Best of luck in your journey treating your depression. It can be exhausting, but it is worth it.

    1.19/5

    1/5

    1/5

    1/5

    1/5

    Reply
    • September 17, 2018 at 8:22 pm
      Permalink

      Hi ☺️
      I just wanted to say that you are a very strong person. I genuinely wish you the best and hope your future is filled with happiness.💕Stay strong 💕

      Reply
    • December 5, 2018 at 5:55 am
      Permalink

      Thank you for taking the time and energy to share! Also, I agree with Nicole, couldn’t had said it any better, and greatly appreciate everyone who does share experiences and helps support those of us going through similar life situations. I recently lost my child because I didn’t know he suffered in silence. He was the strong-willed, intelligent, and hid the depression with making others laugh and lots of silly behavior. I failed to remember how difficult that first year of high school and adolescence was, and the tough act I had to show. Sending lots of love, respect, gratitude, and strength to everyone going through it. Especially those also helping to share an experience or spreading support or awareness and or too many things to list…Thanks from the bottom of my heart.

      Currently taking Sertraline (changed from AM to PM, sertraline is the only change in lifestyle since I started getting numb, tingling, feelings and close to pass out. I’ve lowered dosage and Dr. gave Trintellex samples, I haven’t tried yet. Probably best to find out if I can even get it covered before I try it.

      Reply
    • February 16, 2019 at 3:50 am
      Permalink

      Thank you for your reply! It is very hard to find some one with a bad reaction, but I did. I tried to explain to my dr but I am very sensitive to everything and so far lexapro was the only thing working. He just didn’t understand. I was beginning to have side effects from being on the lexapro, No idea why, but we tried Trintellix. it was very hard to get on. I have to start everything very low for a month before I go up really slow. Anyway, I have a high frunctioning job where I Multitask with 2 to 4 things at a time, and it is very hard. I have to be accurate with alll transactions and Every single number put in Every single time, lol hundred times over every shift and listen to the person on the other phone. Hahaha, I love it but there is no room for error, and with trintellix I felt like it was hitting a black space, black wall if you willl. My congnitive function was suffering. After 3 months I couldn’t recall the most recent actions, like where I had just put the stapler, yet I was running without thought.
      I put my self back on the lexapro and we will see how long it takes to get this crap out of my system. Most ppl have cognitive issues if they are depressed, or on anti-depressants because those pills block your memory, mess it up. However, Lexapro doesn’t do that and I was good. My vision got horrible on Trintellix, really really bad, it was good for fibromyalgia pain, but not at the price of my memory and vision and SLEEP. No I can not do Trintelllix. Lexapro has side effects, but much better tollorated than trintellix. I only hope others will speak up because I know we are not the only ones with issues, and yes I also have high anxiety, PTSD and ADD

      2.38/5

      2/5

      2/5

      2/5

      3/5

      Reply
  • August 22, 2018 at 10:06 pm
    Permalink

    I’m still trying to figure out what is causing SEVERE itching on my arms and hands. I think it may be the Truntellix since I have not had this before.
    It feels as if I want to tear the skin off my bones.
    My arms have scabs all over them from scratching.
    There were no red areas or rash just extreme itching.
    Has anyone else experienced this?

    3.33/5

    5/5

    4/5

    3/5

    1/5

    Reply
    • February 24, 2019 at 5:00 pm
      Permalink

      I’ve been taking it for only 2 weeks. And I’ve taken benadryl the last 3 nights because of itching. I chalked it up to dry skin, not even thinking of the trintellix. It hasn’t been as extreme as you described, but enough to keep me awake and super annoyed. I do not like benadryl much, but it did the job

      3.57/5

      3/5

      3/5

      3/5

      5/5

      Reply
    • July 24, 2019 at 11:51 pm
      Permalink

      Luisa, Trintellix can absolutely cause the insane itching like you’re describing. I take a Zyrtec everyday for allergies anyway but I noticed if I forgot my Zyrtec one day I’d become extremely itchy, especially the bottom of my feet and the palms of my hands for some reason. I asked my doctor about it and she said that is one of the less common side effects. It’s super annoying though.

      2.86/5

      1/5

      2/5

      5/5

      3/5

      Reply
    • September 9, 2019 at 7:32 am
      Permalink

      Started 2 weeks ago and the same thing. Didn’t make the connection. And stomach pains/gas pains like crazy.

      2.86/5

      2/5

      2/5

      5/5

      2/5

      Reply
  • January 8, 2019 at 12:56 pm
    Permalink

    My doctor prescribe this for me to switch me off of Celexa to help reduce side effects. I am on Wellbrutrin which was suppose to counter the Celexa side effects but I have noticed any difference. So Trintellix was the next option. Called my insurance and found out that it is covered but barely. Needless to say I would rather run in front of traffic then pay the cost of this drug. I am asking to return to Celexa and Wellbrutrin. Maybe one day this drug will be available for real people to purchase and not just the wealthy. Not meaning to sound negative, just would have wished to have stayed ignorant to this drugs existence.

    Reply
  • January 13, 2019 at 2:24 am
    Permalink

    Hi 😊 First I would like to thank Hannah for her heartbreaking response. I wish you all success in finding the right fit for you.

    The beginning of my story is similar but my results with Trintellix have been and continue to be very positive. I started with Cellexa for depression, and Zoplicone for sleeping. A couple years later diagnosed Bi-polar. Lamotrigene worked well, but I took myself off twice because I was feeling good. Anti-depressants have a long stigma in my community, and I was tired of people telling me to snap out of it. Trying to take Lamotrigene after quitting was no longer working. My doctor tried two other antidepressants but with one I gained 30 pounds in a few weeks and was still feeling poorly. It got really bad where I wouldn’t leave my home. I laid on the couch wondering if this would be my life forever. I stopped proper hygiene and stopped showering for several weeks at a time. I stopped talking to people and stopped answering the phone, I was hiding at home with the blinds shut and the door locked.
    I felt like I was mute, but crying every day. Then my doctor suggested I try Trintellix, it was the last option before lithium. He had a card for me that would reduce the cost by 90%, so it was then affordable. I was very lucky. Another patient was given the card, however had adverse reaction after the free trials, and returned it. I had no adverse reactions on my trial. No nausea or any of the other possible side effects. After a couple weeks, I began to feel “better”. I was questioning how long would this last? I didn’t want to get too excited, because I was afraid it was too good to be true… It has now been almost 3 years. I feel normal. I forget I even have depression. I have suffered loss, disappointment, non-related medical issues, injuries, but I have not felt depressed in any way and have dealt with each situation calmly. Inside I feel like the happy, charming, talkative person I used to be. I make new friends easily, I travel, I’m working part time, I even started a new business. My life has completely changed for the better. I am so grateful to my doctor and this wonderful drug. I am now 60 years old and my sanity has been restored! I’m looking forward to continued mind-stability for the rest of my life. It has been the best thing that has happened to me in 34 years! I wish everyone could feel as good as I have been feeling for the last 3 years. (Note: I take 20mg Trintellix. I have been taking the following other medication prior to and continue to take: a water pill, Wellbrutin, Trazodone and Zoplicone.)

    Ps. My only complaint is that it is NOT affordable. Without the card, I would not be able to afford it. This drug that has worked so well for me, needs to be affordable so others can hopefully feel a zest for life again.

    Nancy

    Reply
  • March 3, 2019 at 4:33 pm
    Permalink

    Never felt worse in my life from side effects. It’s like having the stomach flu 24/7. Unrelenting stomach pain: heartburn, nausea, gas. And headache. Just miserable.
    And I paid $200 with insurance for this.
    Horrible stuff.

    1.19/5

    1/5

    1/5

    1/5

    1/5

    Reply
  • March 4, 2019 at 12:06 am
    Permalink

    Hi first of all I would like to thank all of you for sharing your experiences and information its soo nice to know I’m not alone in this big old world dealing with bipolar disorder and depression its even worse when your family members and so called friends walk away from you because of being sick I really recieved a lot of information from all of you.I’m soo soo appreciative because I have been soo suicidal lately it’s not even funny I prayed to try to find help and I looked up the medicine and I found all of you thank God All of you don’t know how grateful I am that ur information is put out there for people to read I’m sitting here crying my eyes out because you saved my life God Bless all of you I wish the best to all of you !!! Its time to wean myself off of this medicine I’m taking trintellix.Hannnah I do have to say one thing I felt like I was looking in the mirror when I read ur comments and I’m taking majority of the meds u r taking that’s scary I’m soo grateful again for seeing all of this thank you Hannah / All of You 🤗

    Reply
  • October 7, 2019 at 3:05 pm
    Permalink

    I started Trintellix 3 weeks ago after 60mg of Viibryd did not work for me. Per my doctor’s recommendation I titrated off Viibryd while going onto Trintellix. Week 1 – 40mg of Viibryd, 5mg of Trintellix. Week 2 – 20mg of Viibryd, 10mg of Trintellix, Week 3 – 0mg Viibryd, 10mg of Trintellix. At the beginning of week 3 I tried to go up to 20mg of Trintellix but the effects were severe immediately so I went back down to 10.

    I have been experiencing recurrent and extremely bothersome itchiness with no visible rash. I am not sure if this is a side effect from going on the Trintellix or from coming off of the Viibryd – instances of both effects have been noted online. I have also experienced symptoms of manic behavior since going on the Trintellix. Also constipation and digestive pain. Today I am experiencing tingling in my hands and fingers in particular. One positive is that it restored my energy levels to what feels more normal than the absolutely exhausted state I was in while taking Viibryd. Although my understanding is that sometimes this can be suggestive of Mania.

    Reply
  • October 24, 2019 at 10:50 am
    Permalink

    i been in this medicine for about 1month but dont liked couse make me more sick also is very very expensive i cant afford to pay that much also if i dont going to used why? The waist that medicine make me feel soo sick i dont going to used no more i going back to the other i was using but my dr dont want to put me in more mg just wat he said at first..nice nice no one knows the person struggle..

    Reply
  • November 3, 2019 at 7:48 pm
    Permalink

    I am so grateful for Trintilax. I was taking Lexapro and was falling asleep midday and generally dragging from it. I tried to manage that few a few years by drinking coffee at midday, changing times/dosages with the dr monitoring, but it was basically suppressing my personality and zapping my energy. Sure, I wasn’t depressed, but I was too tired to care, lol.
    Now I’m on Trintillax and it’s a gamechanger. My quality of life has gone up significantly from the change in meds, even my kids noticed that I don’t drag during the day anymore. I take Trintillax and Wellbutrin for depression and OCD tendencies. I’m very grateful for the treatment and meds, it’s made a real difference in my life.
    I did sign up online for a Trintillax ongoing coupon and it reduced the drug cost by 90%. I had to go around the CVS window 4 times the first time until it all got working, but it was worth the hassle. Sign up online with Trintillax.
    P.S. no itching at all, I get occasional acid reflux which I had before the meds. I experienced some tiredness around 6 hours after taking, so I take it an hour or 2 before bedtime. I also get some weird dreams around 8 hours after the dose. Nothing alarming, just weirder than usual without the meds. Still, i get very little depression to the point that I forget I have it. I have seasonal affective disorder, so I still get some seasonal lows, but it’s very much reduced and managed with UV light.

    4.05/5

    5/5

    5/5

    4/5

    2/5

    Reply
  • November 22, 2019 at 8:28 am
    Permalink

    Hi! I’m so happy to have found Trintellix. I’ve tried around 12 antidepressants over the last 20 years, supplements, exercise, you name it. My adult daughter went on Trintellix and has had zero side effects so I asked my doctor for it too. We started on 5 mg for two weeks then went to 10 mg. I’ve had no notable side effects. I feel normal and could tell immediately that my brain was responding. I want to spread the word that this is the smartest antidepressant I’ve tried and possibly ever made. As a serotonin receptor modulator it helps the receptors take up serotonin. I think the receptors May have been my problem all along. It’s been nearly two weeks and I feel ready to go up to 20 mg. As with the 10 mg I know I might have two days of mild headaches but that’s okay. The benefits are amazing. I don’t feel angry, I feel more energized, I don’t feel like a victim anymore. No weight gain, no significant sexual side effects. I’m sleeping better, my anxiety is going way down. It’s gentle. I hope enough people try it so that it can come down in price. My daughter and I both have good insurance and so far it’s been affordable. Try it!

    5/5

    5/5

    5/5

    5/5

    5/5

    Reply
  • November 23, 2019 at 5:47 pm
    Permalink

    I suffer from high anxiety, major depression & frequent panic attacks. I have been on several different drugs. Trintellix seems to have less side effects. However, the price is a real draw back. Overall based on how it works I would recommend.

    3.81/5

    1/5

    5/5

    5/5

    4/5

    Reply
  • December 5, 2019 at 9:46 am
    Permalink

    I suffer from GAD, depression and mild OCD tendencies. When I finally decided I needed help to manage it (in my early 30’s) I went to my family Dr. and listed off a number of things that concerned me about even taking medications. After a long conversation with the doctor he suggested we try Trintellix. I started on 5mg a day, the nausea was bad but I had non drowsy gravel for the first 2 weeks, along with feeling “out of it” and exhausted. I am grateful that I pushed past the initial intake period as I have been on it now for over a year (taking 10mg now). I still have the occasional side effect, such as once in a while I become extremely itchy, and I bruise like a peach now, but I finally have my life back in my control and could not tell you the last time I felt this good.

    4.29/5

    5/5

    2/5

    5/5

    5/5

    Reply

Leave a Reply

Your email address will not be published. Required fields are marked *

APA Reference
Psych Central. (2019). Trintellix. Psych Central. Retrieved on December 5, 2019, from https://psychcentral.com/drugs/trintellix/

 

Scientifically Reviewed
Last updated: 5 Dec 2019
Last reviewed: By Christine Traxler, M.D.
Published on PsychCentral.com. All rights reserved.