Home » Drugs » Trintellix


Generic Name: Vortioxetine (formerly known as Brintellix)

Drug Class: SSRI

Table of Contents







Trintellix (Vortioxetine) is an antidepressant used to treat depression / major depressive disorder in adults. It works by helping to restore the balance of serotonin in the brain. This medication is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator.

Taking this medication may improve your interest in daily living. It may also help stabilize your sleep patterns, mood, appetite, and increase your energy.

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

How to Take It

Take this medicine as directed. It can be taken with or without food. Do not stop taking this medicine abruptly without consulting with your doctor.

Side Effects

Side effects that may occur while taking this medicine include:

  • passing gas
  • spinning sensation
  • dry mouth
  • change in taste
  • constipation
  • heartburn
  • decreased interest in sex
  • blurred vision

Contact your doctor if you experience symptoms that become bothersome, including:

  • agitation
  • increased thirst
  • black stools
  • breathing problems
  • vomiting blood
  • twitching muscles
  • seizures
  • poor coordination

Warnings & Precautions

  • DO NOT use this medication if you are being treated with linezolid or methylene blue injection.
  • Younger adults may experience suicidal thoughts when starting this medication. Be sure to check in regularly with your doctor to monitor your progress.
  • Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant.
  • You may experience dizziness while taking this drug. DO NOT use any type of machinery, drive a vehicle, or perform activities that require alertness until you are confident you can do them safely.
  • Tell your doctor if you have trouble sleeping, anxiety, panic attacks, or are feeling restless, impulsive or irritable.
  • Tell your doctor if you have liver disease, low levels of sodium, if you take blood thinners (or aspirin), or have narrow angle glaucoma.
  • For an overdose, seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Before taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes supplements and herbal products.

Dosage & Missed Dose

Follow all directions exactly as prescribed by your doctor. Your dosage may occasionally be changed by your doctor to ensure the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

If you skip a dose, take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is also not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website:



Overall Review of this Medication

2.9/5 (5 votes)

6 thoughts on “Trintellix

  • May 9, 2017 at 11:45 pm

    I think I’ve tried every antidepressant made. A few have worked much better than others bit more compare to Trintellix. I haven’t had any negative side effects at all. I only wish this medication was affordable..






    • December 29, 2017 at 1:08 pm

      Ask dr for free samples! I first got diarrhea at 5 mg for a week then at 10 mg a week later I had to get off! Got real nauseous& took cola syrup still felt nauseous then threw up! Just another drug poison out there. Will continue counseling but won’t take a drug that also constipates! !!!






  • February 14, 2018 at 4:12 pm

    My son is 13years old , He was prescribed Trintellix 2 months ago.
    My son is High Functioning Autistic, ADHD, Tourettes Syndrome, and PTSD. We can see the how much this medicine has worked in him already!! I wish it wasn’t so expensive. Specially when our insurance wont cover it evan with the Doctor filling out paperwork! Etna is horrible for coving meds that work!!
    Our Son takes Trintellix and Abilify , 10mg each. I highly recommend this drug!!






  • July 7, 2018 at 2:14 pm

    In the 20 or so years that I have been treating my depression/anxiety/BPD/ADHD with medication, I have tried just about every drug on the market. I struggle with treatment resistance, and medications will often work for awhile and then become ineffective after a year or so. I have had periods of medication-induced-mania with other drugs such as Effexor of Zoloft, but have never had a medication-induced-mania as severe as I experienced with Trintellix. Be very careful taking this medication if you are on anything else that increases serotonin levels. I developed a severe allergic reaction and ended up being hospitalized due to the severity. I have never struggled with risk of suicide, and at age 30 I thought that the increased risk of suicidal thoughts and tenancies with this drug would not be as significant for someone out of their teens/early 20’s, but I had incredibly severe suicide ideation. I also developed symptoms of serotonin syndrome and hyponatremia, as well as an allergic reaction. I am on many other medications to deal with PCOS, and my doctor did not warn me of the adverse reactions that Trintellix can have when combined with medications for diabetes, medications that are classified as diuretics, and anti-nausea medications, all of which I am on. Trintellix can also have adverse reactions when combined with stimulants, such as adderall, which I take for ADHD, and anti-anxiety drugs, such as Xanax, which I also take. I assumed that my symptoms were from my drugs for PCOS, and dismissed them for several months, but they ended up so severe that I was taken to the hospital. Check very thoroughly if there are any possible drug interactions before taking Trintellix, because my doctor just glossed right over the fact that I may have interactions with this medication. My symptoms included severe vomiting and nausea, and I was prescribed Zofran, which interacts with Trintellix and can lead to serotonin syndrome. I experienced extreme muscle soreness and fatigue as well as swollen joints. My feet ached continuously and my hands, ankles, and face were swollen. I started having blurred vision, which is still subsiding, even after being off of the drug for a week. I developed a rash all over my face and redness around the eyes, which started going away a few days after being off Trintellix, but is still not completely gone. Trintellix made me have an erratic sleep schedule at best, and my manic symptoms were some of the most frightening things I have ever experienced. Please check with any medical professionals you may visit if you take medications for pain, anti-nausea medications, medications for diabetes or high blood pressure, any other medications for depression/anxiety, any drug that is classified as a ‘water pill’, and any drugs that act as stimulants, or if you consume a lot of caffeine. I do think that this could have been avoided if my psychiatrist was paying more attention to the other medications that my endocrinologist was prescribing for me. My reaction to Trintellix was much more extreme than most people’s, so it may end up being a drug that is worth considering for many people, but please be sure that any other medications and over-the-counter supplements you may take are put into consideration before you begin using this medication. Pricing should also be considered before using this drug. Without insurance, a 30 day supply will cost around $400, and many insurers will require you to try an exhaustive list of medications before they will cover this one. The makers of Trintellix do have a voucher that will enable you to get this medication for $10 a month for up to a year, but you are only eligible for that program if you already have insurance and if your insurance will cover Trintellix. Best of luck in your journey treating your depression. It can be exhausting, but it is worth it.






    • September 17, 2018 at 8:22 pm

      Hi ☺️
      I just wanted to say that you are a very strong person. I genuinely wish you the best and hope your future is filled with happiness.💕Stay strong 💕

  • August 22, 2018 at 10:06 pm

    I’m still trying to figure out what is causing SEVERE itching on my arms and hands. I think it may be the Truntellix since I have not had this before.
    It feels as if I want to tear the skin off my bones.
    My arms have scabs all over them from scratching.
    There were no red areas or rash just extreme itching.
    Has anyone else experienced this?







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APA Reference
Psych Central. (2018). Trintellix. Psych Central. Retrieved on December 12, 2018, from


Scientifically Reviewed
Last updated: 25 Jul 2018
Last reviewed: By John M. Grohol, Psy.D. on 25 Jul 2018
Published on All rights reserved.