Drug Class: Antidepressant, Miscellaneous

Table of Contents


Wellbutrin SR (Bupropion HCL) is classified as an antidepressant used to treat depression. It may improve mood and feeling of well-being.

This drug may also be used in helping to quit smoking as well as treating attention-deficit hyperactivity disorder (ADHD). It may also be used to prevent prevent seasonal affective disorder (SAD) and to treat bipolar disorder (depressive phase). This medication may also be used to treat anxiety in people with depression.

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

It works by helping change certain chemicals in the brain, which professionals refer to as “neurotransmitters.” It is not yet well-understood why changing these neurochemicals results in symptom relief for the conditions this drug is commonly prescribed for.

How to Take It

Follow the directions given to you by your doctor. Swallow the tablet whole. Do not crush or chew before swallowing. This medicine is taken orally and may be taken with food if stomach upset occurs. Take this medicine regularly at the same time every day.

Side Effects

Side effects that may occur while taking this medicine include:

  • dizziness
  • sore throat
  • shaking
  • nausea, vomiting
  • rapid heart beat
  • dry mouth
  • hostility
  • drowsiness
  • itchiness
  • agitation
  • ringing in the ears
  • increased sweating
  • constipation

Contact your doctor immediately if you experience:

  • swelling, redness, or pain in the eyes
  • irregular, pounding, or fast heartbeat
  • unusual weight loss or gain
  • vision changes
  • memory loss or unusual behavior and thinking
  • seizure
  • mental/mood changes e.g., confusion, agitation or anxiety

Warnings & Precautions

  • Do not increase your dose of this medicine without first talking to your doctor, even if you feel that the medicine is not working.
  • This medicine may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine.
  • Do not use this medication if you have been regularly using sedatives and suddenly stopped.
  • Older adults may particularly experience certain side effects of this drug, including dizziness and memory loss.
  • Do not drink alcoholic beverages – alcohol can increase risk of seizures / dizziness.
  • For an overdose, seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Do not take MAO inhibitors type A with this medicine. If you are not sure if you are taking an MAO inhibitor, talk to your doctor or pharmacist. Certain other antidepressants, clozapine (Clozaril), haloperidol (Haldol), lithium, trazadone, and others may increase the risk of seizures. BEFORE taking any new prescription or over-the-counter medicine, talk to your health care provider.

Dosage & Missed Dose

Available as:

Standard pill – 75 mg and 100 mg Sustained-release pill – 100 mg Long-acting extended-release tablet – 150 mg and 300 mg

Pills should be swallowed whole — do not chew, split, or crush them.

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. It is NOT known if this medicine is excreted in breast milk. It is recommended that you DO NOT breast-feed while taking this medicine unless your doctor or pediatrician has told you to.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website, https://www.nlm.nih.gov/medlineplus/druginfo/meds/a695033.html for additional information from the manufacturer of this drug.