Psychological and behavioral therapies, particularly cognitive behavior therapy (CBT), may be effective non-drug treatments for reducing disease-causing inflammation in the body, according to a new review published in the journal JAMA Psychiatry.

For the study, a research team reviewed 56 randomized clinical trials to see whether psychotherapies, typically used for treating mental health problems such as anxiety and depression, might also boost biological processes involved in physical health.

“People automatically go to medication first to reduce chronic inflammation, but medications can be expensive and sometimes have adverse side effects,” said senior author Dr. George Slavich, director of the University of California, Los Angeles (UCLA) Laboratory for Stress Assessment and Research.

“In this review, we wanted to know whether psychotherapies can also affect the immune system and, if so, which ones have the most beneficial effects over the long term.”

Slavich, along with two of his colleagues at UC Davis and San Diego State University, analyzed randomized clinical trials that investigated the effects of several different types of interventions, including CBT, CBT plus medication, grief and bereavement support, a combination of two or more psychotherapies, and psychoeducation, among others.

The team analyzed the duration and types of psychotherapy received, including group versus non-group therapy, and looked at how the treatments affected different markers of inflammation and other immune system processes in the body. Chronic inflammation increases the risk of developing several deadly diseases and can lead to premature death.

Their findings reveal that CBT may be better than other psychotherapies at boosting the immune system.

“This seems to be a case of mind over matter,” Slavich said. “Psychotherapies like CBT can change how we think about ourselves and the world, and changing these perceptions can in turn affect our biology.”

“The results of this study take this idea one step further and suggest that psychotherapy may be an effective and relatively affordable strategy for reducing individuals’ risk for chronic diseases that involve inflammation.”

The researchers looked at several different immune outcomes. Of those outcomes, pro-inflammatory cytokines were most strongly affected by psychotherapy in general and CBT in particular.

Pro-inflammatory cytokines are important because they help the immune system heal physical wounds and battle infections. However, if these proteins remain persistently elevated, they can lead to chronic inflammation, which increases the risk of physical illnesses, such as heart disease, cancer and Alzheimer’s disease, as well as mental health problems, including anxiety disorders, depression, post-traumatic stress disorder (PTSD), schizophrenia, self-harm and suicide.

“There are many people who would prefer to use non-drug interventions for improving their immune system function,” Slavich said. “In some cases, they can’t take certain medications because of medical reasons, and in other instances the medications they need are too expensive. And then there are people who simply prefer a more holistic approach to improving their health.”

Slavich says the findings provide strong evidence that psychotherapy may be helpful in this regard.

“Out of all of the interventions we examined, CBT was the most effective for reducing inflammation, followed by multiple or combined interventions,” Slavich said.

“Moreover, we found that the benefits of CBT on the immune system last for at least six months following treatment. Therefore, if you’re looking for a well-tested, non-drug intervention for improving immune-related health, CBT is probably your best choice.”

Source: University of California- Los Angeles Health Sciences