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Serotonin Tied to Optimism

MRI HeadAlthough an overly optimistic view of the future sometimes leads to underestimating risks and making unrealistic plans, “a moderate optimistic illusion” appears to be essential for maintaining motivation and good mental health.

In a new study, National Institute of Mental Health (NIMH) researchers used functional magnetic resonance imaging (fMRI), to show that “optimism bias” may be rooted in the same brain circuitry as depression, which is marked by a tendency to be overly pessimistic.

The same circuitry was also in play when this normal bias toward positive thinking was temporarily turned off by depriving the brain of the mood-regulating chemical messenger serotonin.

Through this circuit, the anterior cingulate, just behind the front of the brain, regulates the amygdala, an emotion hub deep in the brain.

NIMH researchers set out to discover why, for example, people tend to expect to live longer than average, underestimate their chances of getting a divorce and overestimate their likelihood of successful careers.

Fifteen healthy volunteers were scanned while they were remembering or imagining future events – like “winning an award” and “the end of a romantic relationship” – to see how their brain activity related to their ratings of these experiences and their scores on standard scales of optimism.

True to form, the participants rated future positive events as more vivid and expected them sooner than negative ones.

The cingulate/amygdala circuit showed more activity and connectivity with optimistic than with negative imaginings. The higher an individual scored on rating scales of optimism, the more an area at the front of the cingulate activated. This rostral anterior cingulate appears to be the seat of these judgments, where emotional, motivational and autobiographical information is weighed – with an eye for the positive.

But the same circuit has a flip side. Citing an earlier study the research team pointed out that this cingulate/amygdala circuit may also underlie the pessimism and impaired imagining seen in depression.

In a recent study by Drs. Drevets, Jonathan Roiser, and colleagues, healthy volunteers who had never been depressed lost their optimism bias and showed brain activity changes in similar regions when they lacked tryptophan, the precursor chemical that the body uses to make the chemical messenger serotonin.

This first fMRI study to document neural and behavioral responses to emotionally-charged words when the healthy brain is starved of serotonin was published online September 19, 2007 in Neuropsychopharmacology.

Researchers had previously shown that people with a history of depression experience mood symptoms following such serotonin depletion, along with alterations in emotion-regulating brain circuits.

In the current study, 20 healthy participants initially made significantly more inappropriate responses to positive words while performing a task that required them to respond only to negative words, indicating that their attention was grabbed by the positive words – the optimism bias. However, after they took capsules containing essential amino acids, minus tryptophan, depriving their brains of serotonin, this normal bias toward positive words disappeared.

fMRI scans revealed that this loss of focus on the positive was accompanied by decreased cingulate activity in response to positive stimuli, particularly in a region toward the back of the cingulate cortex that was also implicated in the Phelps study. Drevets and colleagues have proposed that by taking the breaks off the amygdala, such decreased cingulate activity may play a role in depression.

By helping to accentuate the positive, serotonin, which is enhanced by antidepressants, may provide resilience in the face of life’s hard knocks, suggest the researchers.

Source: National Institutes of Public Health

Serotonin Tied to Optimism

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Serotonin Tied to Optimism. Psych Central. Retrieved on April 25, 2019, from
Scientifically Reviewed
Last updated: 8 Aug 2018
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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