Drug Class: SSRI

Table of Contents


Trintellix (Vortioxetine) is an antidepressant used to treat depression / major depressive disorder in adults. It works by helping to restore the balance of serotonin in the brain. This medication is an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator.

Taking this medication may improve your interest in daily living. It may also help stabilize your sleep patterns, mood, appetite, and increase your energy.

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

How to Take It

Take this medicine as directed. It can be taken with or without food. Do not stop taking this medicine abruptly without consulting with your doctor.

Side Effects

Side effects that may occur while taking this medicine include:

  • passing gas
  • spinning sensation
  • dry mouth
  • change in taste
  • constipation
  • heartburn
  • decreased interest in sex
  • blurred vision

Contact your doctor if you experience symptoms that become bothersome, including:

  • agitation
  • increased thirst
  • black stools
  • breathing problems
  • vomiting blood
  • twitching muscles
  • seizures
  • poor coordination

Warnings & Precautions

  • DO NOT use this medication if you are being treated with linezolid or methylene blue injection.
  • Younger adults and teenagers may experience suicidal thoughts when starting this medication. Be sure to check in regularly with your doctor to monitor your progress.
  • Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant.
  • You may experience dizziness while taking this drug. DO NOT use any type of machinery, drive a vehicle, or perform activities that require alertness until you are confident you can do them safely.
  • Tell your doctor if you have trouble sleeping, anxiety, panic attacks, or are feeling restless, impulsive or irritable.
  • Tell your doctor if you have liver disease, low levels of sodium, if you take blood thinners (or aspirin), or have narrow angle glaucoma.
  • For an overdose, seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Before taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes supplements and herbal products.

Dosage & Missed Dose

Follow all directions exactly as prescribed by your doctor. Your dosage may occasionally be changed by your doctor to ensure the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

If you skip a dose, take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is also not known whether this medication passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website: https://www.nlm.nih.gov/medlineplus/druginfo/meds/a614003.html