Research suggests that some nutrient deficiencies, such as vitamins D and B12, are linked to a higher risk of depression.
Depression is a mental health condition that causes symptoms such as low mood, sadness, and irritability. These symptoms occur nearly every day consecutively over a course of 1 week.
Major depression, in particular, is one of the most common mental health disorders, estimated to affect 7.1% of adults in the United States.
Research suggests that certain nutrient deficiencies may put people at a higher risk of developing depression, including deficiencies in vitamins D, B12, and B9.
Although depression caused by a nutritional deficiency may be rare in developed countries, deficiencies may contribute to symptoms of depression if they’re not medically screened for, particularly in people who have other medical conditions that can alter some of these nutrients.
If you experience depressive episodes, you may wonder whether a nutrient deficiency may be behind your symptoms. However, it’s important to keep in mind that depression is complex. Many factors, both environmental and biological, may play a role in causing the condition.
Generally, a variety of approaches are necessary to treat depression and address all the components involved, most commonly talk therapy and medication.
Plus, though there may be a link between nutrient deficiencies and depression, it’s not always clear whether eliminating the deficiency, such as by taking supplements, will reduce depression symptoms.
Still, it may be beneficial to speak with a healthcare professional about getting tested for nutrient deficiencies to see whether they may be an underlying cause for your depression.
Vitamin D can be derived from sunlight as well as some food sources. It’s involved in calcium absorption in the gut, among a variety of other functions, including serotonin regulation.
Scientific evidence suggests that there may be a link between vitamin D deficiency and depression. For instance, a 2018 literature review of 14 studies with a total of 31,424 participants found that deficiencies in this nutrient are associated with depression.
In addition, decreased blood concentrations of vitamin D have been linked to inflammation, which has also been associated with depression.
These findings led to a
A possible explanation for the link between low blood levels of vitamin B12 and depression is the “homocysteine hypothesis,” which
Since some B vitamins, including vitamin B12, B9, and B6, are involved in homocysteine metabolism, it’s been theorized that low blood levels of these vitamins may lead to excess homocysteine, which in turn may affect brain functioning, leading to changes in mood and depressive symptoms.
Still, it’s unclear whether supplementing with vitamin B12 has a positive effect on depressive symptoms or depression. But
Vitamin B12 is mainly found in animal-derived foods. Liver, kidneys, beef, and clams are some of the richest sources of this nutrient.
For this reason, it may be more difficult for people who don’t eat animal foods to get enough B12 through their diet. Still, some plant foods like seaweed or mushrooms may contain B12, and some products like nondairy milk replacements, nutritional yeast, or cereals may be fortified with the vitamin.
Keep in mind that insufficient dietary intake may not be the only possible cause of vitamin B12 deficiency. Other causes
- a lack of intrinsic factor due to pernicious anemia
- taking certain medications like metformin or proton pump inhibitors for a long time
- surgery on your gastrointestinal tract
Folate (vitamin B9) is a B vitamin that’s found naturally in many foods. It’s involved in cell division, DNA, and other important biological processes.
Deficiency in this nutrient is associated with depression, and supplementing with this vitamin has been found to be beneficial for people with depression, especially for those with treatment-resistant depression.
Folate and its synthetic form folic acid are found in many foods including:
- leafy greens
- citrus fruits
- fortified grains
Getting too much of the synthetic form of vitamin B9 — folic acid — in supplemental form may have harmful effects, so it’s best to get vitamin B9 from food sources.
Magnesium is an essential micronutrient for many biological processes. Hypotheses that magnesium deficiency may be linked to depression are
Still, though one study showed that participants who had a magnesium deficiency as well as depression experienced improved depression symptoms after supplementing with magnesium, clinical
Food sources of magnesium include:
- green leafy vegetables
- whole grains
Daily recommendations for this nutrient vary depending on your age and sex, but the
Iron is a mineral vital for the body’s growth and development. Iron deficiency is one of the most common deficiencies worldwide. It affects women more than men. In fact, one study found that 57.5% of female participants had lower levels of iron, compared with 7.6% of male participants.
In severe cases, iron deficiency develops into iron deficiency anemia (IDA), which is when iron blood levels are so low that they negatively affect red blood cell production.
Some evidence suggests a possible association between iron deficiency and depression. For instance, in
Some research found that people with IDA who took an iron supplement experienced a significant decrease in psychiatric disorders, including depression, compared with people with IDA who did not take an iron supplement.
These findings indicate that for people who have iron deficiency anemia or show signs of iron deficiency anemia in addition to depression, treating and managing this condition may prevent depression.
Still, more research is needed on the link between iron deficiency and depression and whether taking an iron supplement may be beneficial.
Zinc is an essential trace element crucial for brain growth and development. It’s also involved in cellular metabolism, a set of chemical processes that fuel our cells and keep us alive.
Having balanced zinc levels is vital for zinc homeostasis in various parts of the brain, including those associated with depression, such as the hippocampus, amygdala, and cerebral cortex. This means that zinc levels are in a constant, stable state, making for optimal function within those brain areas.
Omega-3 fatty acids
Omega-3s are fatty acids involved in enhancing brain function and reducing inflammation.
Your body cannot produce omega-3s. You need to get them from foods or supplements. Foods rich in omega-3s include fatty fish, nuts, and plant oils.
Limited research suggests that deficiencies in manganese and selenium may be associated with depression. However, it’s important to keep in mind that deficiencies in these nutrients are extremely rare.
Manganese is a mineral nutrient that humans need in small amounts. It’s plentiful through some food sources, which is why manganese deficiency is quite rare.
Although a deficiency in manganese has been linked to depressive and anxiety symptoms
Foods rich in manganese include:
- whole grains
- leafy vegetables
- black pepper
Selenium is a vital trace element and crucial for brain function. It’s also involved in proper thyroid function.
Selenium has been suspected to play a role in the development of depression. However, studies have not been consistent about its exact role.
Selenium can be derived from seafood, poultry, dairy, and eggs. Most adults are recommended to consume around 55 mcg of selenium daily by the
If you suspect a vitamin deficiency may be contributing to symptoms of depression, it can help to speak with your doctor about it. They may recommend a blood test to confirm any possible deficiencies.
Once you know for sure whether you have a nutrient deficiency, you and your treatment team can discuss whether taking a supplement may be worth a try. Ideally, your primary care physician or internist and your therapist or psychiatrist should collaborate to determine the best treatment plan.
It’s important not to add any new supplements to your diet before talking to a healthcare professional first, as they can help find the ideal dose and determine if there are any potential medication interactions or side effects.
It’s good to keep in mind that evidence is often lacking as to whether taking a supplement to treat a deficiency may also reduce depression symptoms. Don’t be discouraged if a supplement doesn’t help. Depression is highly treatable, and you and your doctor can figure out the right treatment plan for you.
Treatment plans often involve a multifaceted approach, including therapy, medication, dietary changes, supplementation, and various self-help strategies.
Easing symptoms can take time, so do your best to stay patient. Try to be honest with yourself, your loved ones, and your care team about your experience with depression to find the best treatment options for you.