New research suggests lifestyle choices coupled with the emotional stress of social isolation and interpersonal conflicts may increase the risk for contracting COVID-19.
Investigators explain that lifestyle refers to practices such as smoking, exercise and other behaviors generally associated with risk factors for certain cancers and cardiovascular disease.
A growing body of research reveals that these risk factors and a lack of supportive social connections can also increase the risk of developing respiratory infections, like the common cold and influenza. Investigators from Carnegie Mellon University believe these factors can also influence susceptibility to COVID-19.
“We know little about why some of the people exposed to the coronavirus that causes COVID-19 are more likely to develop the disease than others,” said Dr. Sheldon Cohen, a professor of psychology and one of the authors on the paper.
“Our research on psychological factors that predict susceptibility to other respiratory viruses may provide clues to help identify factors that matter for COVID-19.”
The study appears in the journal Perspectives on Psychological Science.
Investigators have studied how lifestyle, social, and psychological factors affect whether or not healthy adults exposed to respiratory viruses become ill through a series of studies spanning more than 30 years. In the recent study, Cohen and his team focused on eight viral strains that cause the common cold and two that cause influenza.
“In our work, we intentionally exposed people to cold and influenza viruses and studied whether psychological and social factors predict how effective the immune system is in suppressing infection, or preventing or mitigating the severity of illness,” said Cohen. “We found a strong correlation between social and psychological stressors and increased susceptibility.”
Intriguingly, the researchers also found that social integration and social support offer a protective shield against respiratory infection and illness.
Until now, the only tactics to slow the spread of coronavirus have been behavioral changes that reduce the probability of being exposed to the virus, such as stay-at-home measures and social-distancing requirements. These same behaviors, however, are often associated with interpersonal stressors, like loneliness, loss of employment, and familial conflict.
According to the researchers, these stressors may be powerful predictors of how a person will respond if exposed to coronavirus because of the stressors’ direct physiological effects on immunity and their psychological factors. These elements are thought to have their influence through the mind-body connection.
Cohen’s work demonstrates that psychological and social stressors are associated with an overproduction of proinflammatory chemicals known as cytokines in response to cold and influenza viruses. In turn, this excess of inflammation was associated with an increased risk of becoming ill.
Similarly, research on COVID-19 has shown that producing an excess of proinflammatory cytokines is associated with more severe COVID-19 infections. This suggests a stress-triggered excessive cytokine response might also contribute to excessive inflammation and symptoms in COVID-19 patients.
Cohen and his colleagues acknowledge that, as of now, there are no firmly established links between behavioral and psychological factors and the risk for disease and death in persons exposed to the corona virus that causes COVID-19.
However, their prior body of research may be relevant to the current pandemic because, they note, the most potent predictors of disease, interpersonal and economic stressors, are the types of stressors that are commonly experienced among those who are isolated or in quarantine.
“If you have a diverse social network (social integration), you tend to take better care of yourself (no smoking, moderate drinking, more sleep and exercise),” said Cohen. “Also, if people perceive that those in their social network will help them during a period of stress or adversity (social support) then it attenuates the effect of the stressor and is less impactful on their health.”