A new study from Johns Hopkins Medicine suggests that being around dogs from an early age may reduce the chance of developing schizophrenia as an adult.
“Serious psychiatric disorders have been associated with alterations in the immune system linked to environmental exposures in early life, and since household pets are often among the first things with which children have close contact, it was logical for us to explore the possibilities of a connection between the two,” said lead author Robert Yolken, M.D., chair of the Stanley Division of Pediatric Neurovirology and professor of neurovirology in pediatrics at the Johns Hopkins Children’s Center.
For the study, researchers from the Sheppard Pratt Health System in Baltimore investigated the link between exposure to a household pet cat or dog during the first 12 years of life and a later diagnosis of schizophrenia or bipolar disorder.
The researchers found a statistically significant decrease in the risk of a person developing schizophrenia if exposed to a dog early in life. Across the entire age range studied, there was no significant link between dogs and bipolar disorder, or between cats and either psychiatric disorder.
The researchers warn that more studies are needed to confirm these findings, to search for the factors behind any strongly supported links, and to more precisely define the actual risks of developing psychiatric disorders from exposing infants and children under age 13 to pet cats and dogs.
Previous studies have identified early life exposures to pet cats and dogs as environmental factors that may alter the immune system through various means, including allergic responses, contact with zoonotic (animal) bacteria and viruses, changes in a home’s microbiome, and pet-induced stress reduction effects on human brain chemistry.
Some investigators, Yolken notes, suspect that this “immune modulation” may alter the risk of developing psychiatric disorders to which a person is genetically or otherwise predisposed.
In the new study, the research team observed a group of 1,371 men and women, ages 18 to 65; 396 participants had schizophrenia, 381 had bipolar disorder and 594 were controls.
Patients with schizophrenia and bipolar disorder were recruited from inpatient, day hospital and rehabilitation programs of Sheppard Pratt Health System. Control group members were recruited from the Baltimore area and were screened to rule out any current or past psychiatric disorders.
All participants were asked if they had a household pet cat or dog or both during their first 12 years of life. Those who reported that a pet cat or dog was in their house when they were born were considered to be exposed to that animal since birth.
The findings suggest that people who were exposed to a pet dog before their 13th birthday were significantly less likely — as much as 24% — to be diagnosed later with schizophrenia.
“The largest apparent protective effect was found for children who had a household pet dog at birth or were first exposed after birth but before age 3,” he said.
If the findings are reflective of the greater population, then 840,000 cases of schizophrenia (24% of the 3.5 million people diagnosed with the disorder in the United States) might be prevented by pet dog exposure or other factors associated with pet dog exposure.
“There are several plausible explanations for this possible ‘protective’ effect from contact with dogs — perhaps something in the canine microbiome that gets passed to humans and bolsters the immune system against or subdues a genetic predisposition to schizophrenia,” Yolken says.
For bipolar disorder, the study results suggest there is no risk association, either positive or negative, with being around dogs as an infant or young child.
Overall for all ages examined, early exposure to pet cats was neutral as the study could not link felines with either an increased or decreased risk of developing schizophrenia or bipolar disorder.
“However, we did find a slightly increased risk of developing both disorders for those who were first in contact with cats between the ages of 9 and 12,” Yolken says. “This indicates that the time of exposure may be critical to whether or not it alters the risk.”
One example of a suspected pet-borne trigger for schizophrenia is the disease toxoplasmosis, a condition in which cats are the primary hosts of a parasite transmitted to humans via the animals’ feces.
Pregnant women have been advised for years not to change cat litter boxes to eliminate the risk of the illness passing through the placenta to their fetuses and causing a miscarriage, stillbirth, or potentially, psychiatric disorders in a child born with the infection.
In a 2003 review paper, Yolken provided evidence from multiple epidemiological studies showing a statistical connection between a person exposed to the parasite that causes toxoplasmosis and an increased risk of developing schizophrenia.
The researchers found that a large number of people in those studies who were diagnosed with serious psychiatric disorders, including schizophrenia, also had high levels of antibodies to the toxoplasmosis parasite.
Because of this finding and others like it, most research has focused on investigating a potential link between early exposure to cats and psychiatric disorder development. Yolken says the most recent study is among the first to consider contact with dogs as well.
“A better understanding of the mechanisms underlying the associations between pet exposure and psychiatric disorders would allow us to develop appropriate prevention and treatment strategies,” Yolken says.
The findings are published in the journal PLOS One.
Source: Johns Hopkins Medicine