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Smoking May Hike Risk of Depression, Schizophrenia

A new investigation from the U.K. suggests tobacco smoking may increase the risk of developing depression and schizophrenia. University of Bristol researchers believe the study adds to a growing body of work suggesting that smoking can have adverse effects on mental health.

It is well-known that smoking is much more common among people with mental illness, especially depression and schizophrenia. However, most studies that have looked at this association have not been able to determine if this is a cause-and-effect relationship.

Moreover, if is does have a reciprocal relationship, which factor causes the other? Does mental illness increase the likelihood of smoking, or is smoking itself a risk factor for mental illness?

The researchers were part of the university’s Tobacco and Alcohol Research Group (TARG) with support from Bristol’s MRC Integrative Epidemiology Unit (IEU) and the NIHR Bristol Biomedical Research Centre (BRC). For the study, they used UK Biobank data from 462,690 individuals of European ancestry, comprising 8 percent current smokers and 22 percent former smokers.

The team applied an analytic approach called Mendelian randomization, which uses genetic variants associated with an exposure (e.g. smoking) to support stronger conclusions about cause-and-effect relationships.

They found evidence that tobacco smoking increased risk of depression and schizophrenia, but also that depression and schizophrenia increase the likelihood of smoking (although the evidence was weaker in this direction for schizophrenia).

The same group published a similar study in British Journal of Psychiatry earlier this year in collaboration with the University of Amsterdam, showing evidence that tobacco smoking increases the risk of bipolar disorder.

The UK government’s mental health task force made the recommendation in their 2016 review that psychiatric hospitals should be smoke free by 2018. This new evidence adds further weight to support the implementation of smoke-free policies.

Not only is there evidence that smoking can be detrimental for mental health, but much of the excess mortality associated with mental illness is due to smoking.

Said Dr. Robyn Wootton, senior research associate in the School of Experimental Psychology and the study’s lead author, “Individuals with mental illness are often overlooked in our efforts to reduce smoking prevalence, leading to health inequalities. Our work shows that we should be making every effort to prevent smoking initiation and encourage smoking cessation because of the consequences to mental health as well as physical health.”

Marcus Munafò, professor of biological psychology in Bristol’s School of Psychological Science and senior author on the study, added, “The increasing availability of genetic data in large studies, together with the identification of genetic variants associated with a range of behaviors and health outcomes, is transforming our ability to use techniques such as Mendelian randomization to understand causal pathways.

“What this shows is that genetic studies can tell us as much about environmental influences — in this case the effects of smoking on mental health — as about underlying biology.”

The research appears in the journal Psychological Medicine.

Source: University of Bristol

Smoking May Hike Risk of Depression, Schizophrenia

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2019). Smoking May Hike Risk of Depression, Schizophrenia. Psych Central. Retrieved on December 3, 2020, from
Scientifically Reviewed
Last updated: 7 Nov 2019 (Originally: 7 Nov 2019)
Last reviewed: By a member of our scientific advisory board on 7 Nov 2019
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