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Old Brain Injury May be Cause of Dementia, Not Alzheimer’s

A new study suggests MRI scans can help to determine if memory loss is caused by Alzheimer’s disease or traumatic brain injury (TBI). Researchers say the differentiation is important because it could help prevent a misdiagnosis of Alzheimer’s disease, which can be devastating for patients and their families.

Researchers from UCLA, along with colleagues at Washington University in St. Louis discovered that in one study, as many as 21% of older adults with dementia may be misdiagnosed with Alzheimer’s disease. A misdiagnosis can result in patients not receiving the appropriate treatment, and it prevents them from participating in clinical trials that could improve their overall care.

The current study included 40 UCLA patients with an average age of just under 68, who had suffered traumatic brain injury, or a TBI, and later developed memory problems. According to the U.S. Centers for Disease Control and Prevention, 2.87 million Americans experienced TBI in 2014, with the rates highest for people age 75 or older.

Serious brain injury often happens as a result of a fall, an event children age 4 and younger, and adults age 65 and older are most likely to suffer. The study appears in the Journal of Alzheimer’s Disease.

“We already knew that MRIs can reveal subtle abnormalities in patients with neurological disorders, such as Alzheimer’s,” said Dr. Somayeh Meysami, lead author and a postdoctoral clinical research at the David Geffen School of Medicine at UCLA.

“The purpose of our study was to evaluate whether MRI also could reveal distinct abnormalities in traumatic brain injury. And, if we could identify such a pattern, it would lead to improved diagnosis of TBI-related memory loss from other causes of dementia.”

Using a software program to analyze the MRI scans, the study revealed that TBI caused the most damage to a brain region known as the ventral diencephalon, with the least amount of atrophy occurring in the hippocampus, said study author Dr. Cyrus Raji, an assistant professor of radiology at Washington University in St. Louis.

The ventral diencephalon is associated with learning and emotions, whereas the hippocampus is involved in memory and emotions. The hippocampus also is the region of the brain that is most impacted by Alzheimer’s disease.

“The method we used to measure brain volumes in these individuals is useful because it can be applied on the same type of MRI scans we obtain in the clinic with no special type of imaging required,” Dr. Raji said.

The Alzheimer’s Association estimates that up to 40 percent of dementias are caused by conditions other than Alzheimer’s disease.

“Our study offers further evidence that not all memory loss is caused by Alzheimer’s disease,” he said. “It can attributed to TBI, as well as other dementias and neurodegenerative disorders,” said Dr. Mario Mendez, a professor-in-residence at the David Geffen School of Medicine at UCLA.

Source: UCLA Health

Old Brain Injury May be Cause of Dementia, Not Alzheimer’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2019). Old Brain Injury May be Cause of Dementia, Not Alzheimer’s. Psych Central. Retrieved on December 2, 2020, from
Scientifically Reviewed
Last updated: 1 Nov 2019 (Originally: 1 Nov 2019)
Last reviewed: By a member of our scientific advisory board on 1 Nov 2019
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