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Hysterectomy Tied to Greater Risk of Depression, Anxiety

A new study finds that women who have had a hysterectomy are at greater risk for long-term depression and anxiety. The risk for depression is even greater among women younger than 36.

Mayo Clinic researchers reviewed the health records of nearly 2,100 women who underwent the removal of their uterus, but not the ovaries, between 1980 and 2002.

The study, which used data from the Rochester Epidemiology Project, considered only new diagnoses of depression, anxiety, dementia, substance abuse and schizophrenia after hysterectomy, and excluded women with previous diagnoses.

Researchers found an absolute risk increase of 6.6% for depression and 4.7% for anxiety over 30 years. For women who underwent hysterectomy between the ages of 18 and 35, the risk of depression was higher, with absolute risk increase over 30 years of 12%.

“Our study shows that removing the uterus may have more effect on physical and mental health than previously thought,” said senior author Shannon Laughlin-Tommaso, M.D., a Mayo Clinic OB-GYN. “Because women often get a hysterectomy at a young age, knowing the risks associated with the procedure even years later is important.”

Laughlin-Tommaso says several treatments for benign gynecological conditions are available that would allow a woman to avoid hysterectomy. “Those alternatives should be tried before going to hysterectomy, especially at a young age,” she said.

The study is one of two Mayo Clinic studies published online by Menopause: The Journal of the North American Menopause Society. These studies examine the links between hysterectomy with or without removal of the ovaries and women’s mental health.

The second study, also based on data from the Rochester Epidemiology Project, finds that women who had both ovaries removed without an indication of malignancy were more likely to have preexisting mood disorders, anxiety disorders or other less common psychological disorders.

The researchers looked at the health records of 1,653 premenopausal women who had their ovaries removed at the time of hysterectomy, most to avoid or minimize the risk of ovarian or breast cancer. Researchers identified several psychiatric conditions that may have influenced women to decide to request surgery, or a primary care doctor or gynecologist to endorse or suggest surgery.

“We can say that psychological conditions may have played an important role in the decision to perform hysterectomy, with or without removal of the ovaries,” said senior author Walter Rocca, M.D., a Mayo Clinic neurologist and epidemiologist.

“Understanding the psychiatric conditions that may have influenced the past practice of hysterectomy is important for developing more conservative strategies in the future.”

Source: Mayo Clinic

Hysterectomy Tied to Greater Risk of Depression, Anxiety

Traci Pedersen

Traci Pedersen is a professional writer with over a decade of experience. Her work consists of writing for both print and online publishers in a variety of genres including science chapter books, college and career articles, and elementary school curriculum.

APA Reference
Pedersen, T. (2019). Hysterectomy Tied to Greater Risk of Depression, Anxiety. Psych Central. Retrieved on November 23, 2020, from
Scientifically Reviewed
Last updated: 7 Sep 2019 (Originally: 8 Sep 2019)
Last reviewed: By a member of our scientific advisory board on 7 Sep 2019
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