New research has found that gentle sound stimulation — known as pink noise — played during specific times during deep sleep enhances deep or slow-wave sleep for people with mild cognitive impairment, who are at risk for Alzheimer’s disease.
The individuals whose brains responded the most robustly to the sound stimulation showed an improved memory response the following day, researchers discovered.
“Our findings suggest slow-wave or deep sleep is a viable and potentially important therapeutic target in people with mild cognitive impairment,” said Dr. Roneil Malkani, an assistant professor of neurology at Northwestern University Feinberg School of Medicine and a Northwestern Medicine sleep medicine physician. “The results deepen our understanding of the importance of sleep in memory, even when there is memory loss.”
Deep sleep is critical for memory consolidation, the researcher said, noting sleep disturbances have been observed in people with mild cognitive impairment. The most pronounced changes include a reduced amount of time spent in the deepest stage of sleep, he noted.
Because the new study was small — just nine participants — and some individuals responded more robustly than others, the improvement in memory was not considered statistically significant, he said.
However, there was a significant relationship between the enhancement of deep sleep by sound and memory: The greater the deep sleep enhancement, the better the memory response, according to the study’s findings.
“These results suggest that improving sleep is a promising novel approach to stave off dementia,” Malkani said.
For the study, Northwestern scientists conducted a trial of sound stimulation overnight in people with mild cognitive impairment. Participants spent one night in the sleep laboratory, returning about a week later for another night.
Each participant received sounds on one of the nights and no sounds on the other. The order of which night had sounds or no sounds was randomly assigned, the researchers explained.
Participants did memory testing the night before and again in the morning. Scientists then compared the difference in slow-wave sleep with sound stimulation and without sounds, and the change in memory across both nights for each participant.
The participants were tested on their recall of 44 word pairs. The individuals who had 20 percent or more increase in their slow wave activity after the sound stimulation recalled about two more words in the memory test the next morning. One person with a 40 percent increase in slow wave activity remembered nine more words.
The sound stimulation consisted of short pulses of pink noise, similar to white noise but deeper, during the slow waves. The system monitored the participant’s brain activity. When the person was asleep and slow brain waves were seen, the system delivered the sounds. If the patient woke up, the sounds stopped playing.
“As a potential treatment, this would be something people could do every night,” Malkani said.
The next step is to evaluate pink noise stimulation in a larger sample of people with mild cognitive impairment over multiple nights to confirm memory enhancement and see how long the effect lasts, Malkani said.
The study was published in the Annals of Clinical and Translational Neurology.
Source: Northwestern University