Investigators from the Vanderbilt University Medical Center found that children and young adults without psychosis who are prescribed high-dose antipsychotic medications are at increased risk of unexpected death.
Unexpected death includes deaths due to unintentional drug overdose or cardiovascular/metabolic causes. The study appears in JAMA Psychiatry.
However, antipsychotics have potentially life-threatening effects, even in younger populations, and there are other medications for many of these conditions.
Wayne Ray, Ph.D., senior author of the study believes the findings reinforce guidelines for cautious use of antipsychotics in younger populations.
“Patients should be selected very carefully, after consideration of both drug- and non-drug-alternatives,” Ray said. “There should be a pre-treatment evaluation for factors that might amplify antipsychotic effects, such as cardiac conditions. These children and young adults should also be thoroughly monitored during treatment if they are prescribed a high-dose antipsychotic.”
Study authors searched data for about 250,000 relatively healthy children and young people (ages 5 to 24) enrolled in the Tennessee Medicaid program from January 1999 through December 2014, including new users of antipsychotic medications who received higher or lower doses and a comparison group of new users of control medications that weren’t antipsychotics.
Patients with schizophrenia or other psychoses were excluded because there are no alternatives to antipsychotics for these conditions.
The high-dose antipsychotic group of children and young adults ages 5-24 had a 3.5-fold increased risk of unexpected death, when compared with their peers in the study, while the risk for cardiovascular and metabolic deaths was increased 4.3-fold.