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Changes in Brain Connectivity ID'd in Toddlers with Autism

Changes in Brain Connectivity ID’d in Toddlers with Autism

New research reveals that infants who display reduced sensitivity and attention towards social cues during the first year of life are often later diagnosed with an autism spectrum disorder (ASD).

Scientists believe this apparent indifference to social cues hinders the normal development of the social brain at early developmental stages. This new knowledge may open the way to new therapeutic interventions at early stages when neural plasticity is still possible.

As infants develop, they preferentially move towards and respond to social cues such as voices, faces, and human gestures. At the same time, their brain develops a network of regions that specialize in translating these cues, known as the “social brain.”

In a new study, a team of researchers from the University of Geneva (UNIGE), Switzerland, found direct evidence of this hindered development during the toddler to preschool years in autism.

Their findings are published in the journal eLife.

The results of their study suggest that interventions targeting children’s ability to respond to social cues at this critical early age could rewire the brain while it is still possible to do so, potentially restoring social brain development.

Dr. Holger Sperdin, postdoctoral research associate at the UNIGE’s Faculty of Medicine and lead author of the study, explains:

“As toddlers with ASD have less preferential attention for social cues, we hypothesized that when we showed them moving social images, they would demonstrate differences in both the way they visually explore these images and in the way their brain networks process social information, compared with typically developing toddlers.”

The team used an electrophysiological monitoring method called electroencephalography (EEG) to study the children’s brain activity, and powerful eye-tracking technology to observe their gaze while they watched movies featuring human social interactions.

They found that the children with ASD had different gaze patterns while watching the movies to the typically developing infants, and that this was accompanied by alterations in nerve cell connectivity and information flow in the brain.

In those with ASD, the team also observed what is known as “increased driving” in two specific frequencies of brain waves — alpha and theta — as well as high levels of connectivity between nerve cells in certain regions in the brain.

The theta brain wave frequency and the regions of the brain affected are both known to be important components of the social brain, and the alpha frequency is important for visual attention.

These findings represent the first evidence that differences in the visual exploration of images coincide with changes in connectivity between key regions of the social brain in very young children with ASD. Brain regions generating these brain wave frequencies may therefore develop differently in children with ASD compared with their typically developing peers.

“Our results show for the first time the presence of alterations in information flow from brain areas involved in social cue processing in toddlers and preschoolers with autism spectrum disorders (ASD),” said senior author Professor Marie Schaer.

“These alterations within regions of the social brain are present at early stages of ASD and justify further investigation into whether therapeutic interventions targeting social orienting skills may help to remediate social brain development during this critical stage when neural plasticity is still possible.”

Source: University of Geneva (UNIGE)

Changes in Brain Connectivity ID’d in Toddlers with Autism

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Changes in Brain Connectivity ID’d in Toddlers with Autism. Psych Central. Retrieved on November 25, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 28 Feb 2018)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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