Virtual reality entails presenting our senses with a computer generated virtual environment that we can explore in some fashion. A new study uses the technique to help neuroscientists obtain insight into how different brain areas assemble memories in context.
It’s well known that one memory can trigger related memories. We remember specific events with context — when and where it happened, who was there. Different memories can also have specific context, as well as information that is the same between memories — for example, events that occurred in the same location.
Graduate student Halle Dimsdale-Zucker and Professor Charan Ranganath at the University of California, Davis Center for Neuroscience and Department of Psychology studied how the brain assembles all the pieces of these memories.
They use functional magnetic resonance imaging, or fMRI, to look for brain areas that are activated as memories are recalled, especially in the hippocampus, a small structure in the center of the brain.
For this study, Dimsdale-Zucker used architectural sketching software to build houses in a 3-D virtual environment. The subjects watched a series of videos in which they went into one house then another.
In each video, different objects were positioned within the houses. The subjects therefore memorized the objects in two contexts: which video (episodic memory) and which house (spatial memory).
In the second phase of the study, the subjects were asked to try to remember the objects while they were scanned by fMRI. Being asked about the objects spontaneously reactivated contextual information, Dimsdale-Zucker said.
She discovered different regions of the hippocampus were activated for different kinds of information: One area, CA1, was associated with representing shared information about contexts (e.g., objects that were in the same video); another, distinct area was linked to representing differences in context.
“What’s exciting is that it is intuitive that you can remember a unique experience, but the hippocampus is also involved in linking similar experiences,” Dimsdale-Zucker said. “You need both to be able to remember.”
Another interesting finding was that in this study, the hippocampus was involved in episodic memories linking both time and space, she said.
This observation was contrary to conventional beliefs that the hippocampus codes primarily for spatial memories, for example those involved in navigation.
Virtual reality makes it possible to carry out controlled laboratory experiments with episodic memory, Dimsdale-Zucker said.
The knowledge gained on how memories are formed, stored and recalled could eventually lead to better diagnosis and treatment for memory problems in aging or degenerative disorders such as Alzheimer’s disease.
Source: University of California, Davis