Psychotic Symptoms Tied to Altered Brain Dynamics

A new study finds that healthy people who experience subtle symptoms like those in psychotic disorders, such as hallucinations and delusions, have altered brain dynamics — alterations in patterns of brain activity that reoccur, or “states” that the brain moves in and out of over time.

Previous studies of PLEs have found alterations in specific brain networks, but the findings reveal that it is not just damaged connections but the amount of time in uncommon brain states that may contribute to psychosis.

“These altered brain dynamics are important because they provide a new biomarker for subclinical psychosis,” said Dr. Anita Barber of the Feinstein Institute for Medical Research in New York, first author of the study. It appears in the journal Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.

The participants were all considered healthy, yet their subtle symptoms demonstrated unique brain fluctuations that could potentially be used to identify signs of psychosis.

In the study, Barber and colleagues analyzed brain imaging data from the Human Connectome Project of 76 otherwise healthy participants reporting PLEs and 153 control participants. Those experiencing PLEs spent less time in a more “typical” reoccurring brain state involving cognitive networks.

They also spent more time in a state characterized by excessive communication in visual regions of the brain, which could be the basis for visual hallucinations experienced in psychosis.

The study didn’t include people with a psychotic disorder, but the findings line up with brain alterations found in patients with schizophrenia.

According to Dr. Cameron Carter, Editor of Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, the study is an important example of how sophisticated imaging techniques improve diagnostic capabilities.

Carter said technology can measure altered brain dynamics during brain transitions. The new data is then used to identify subtle risk states or even track the transition from subclinical to clinical psychopathology.

“This has implications for improving health and well-being and for preventing conversion to a psychotic disorder,” said Barber.

PLEs affect many more people than the number who will be diagnosed with a psychotic disorder, and can cause impairments in social and occupational functioning similar to, though less severe than, those experienced by people with psychosis.

Source: Elsevier