Researchers from the University of Seville have patented a pain relief approach that uses nanotechnology to deliver a cannabinoids-based formula to relieve chronic neuropathic pain.
Investigators say a scheduled release of the cannabinoid provided neuropathic pain relief in rats for a period of eleven days after the oral administration of a single dose.
Cannabinoids are classes of chemical compounds that act on specific brain receptors in cells that alter neurotransmitter release; they can be produced naturally in the body, derived from cannabis and other plants or manufactured synthetically.
The innovative approach is based on using polymer nanoparticles to deliver active ingredients. Nanotechnology is used to encapsulate the main active ingredients in a polymer matrix composite. In this way, it is possible to extend the therapeutic effect while reducing the necessary dosage.
In addition, the active ingredients cannot cross the blood-brain barrier, which removes any potential psychoactive effect.
Researchers believe the new technology will be a very important advance in the treatment of chronic pain.
The research appears in Nanomedicine: Nanotechnology, Biology, and Medicine.