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Mouse Study Finds Stress Can Take Physical Toll as Badly as Junk Food

Mouse Study Finds Stress Can Take Physical Toll as Badly as Junk Food

A new study from Brigham Young University finds that stress damages the GI system of mice in a similar manner as junk food, especially among females.

Dr. Laura Bridgewater, a professor of microbiology and molecular biology found that when female mice were exposed to stress, their gut microbiota — the microorganisms vital to digestive and metabolic health — changed to look like the mice had been eating a high-fat diet.

The study appears in Nature Scientific Reports.

“Stress can be harmful in a lot of ways, but this research is novel in that it ties stress to female-specific changes in the gut microbiota,” Bridgewater said.

“We sometimes think of stress as a purely psychological phenomenon, but it causes distinct physical changes.”

Bridgewater and her collaborators at Shanghai Jiao Tong University in China took a large group of eight week-old mice and exposed half of the males and half of the females to a high-fat diet. After 16 weeks, all of the mice were exposed to mild stress over the course of 18 days.

Researchers then extracted microbial DNA from the mice fecal pellets before and after the stress to test how the gut microbiota was affected. They also measured mouse anxiety based on how much and where the mice traveled in an open field arena.

The researchers found fascinating differences between genders: Male mice on the high-fat diet exhibited more anxiety than females on the high-fat diet, and high-fat males also showed decreased activity in response to stress.

However, it was only in female mice that stress caused the gut microbiota composition to shift as if the animals were on a high-fat diet.

While the study was only carried out on animals, researchers believe there are could be significant implications for humans.

“In society, women tend to have higher rates of depression and anxiety, which are linked to stress,” said Bridgewater, who also serves as associate dean of the BYU College of Life Sciences.

“This study suggests that a possible source of the gender discrepancy may be the different ways gut microbiota responds to stress in males vs. females.”

Source: Brigham Young University

Mouse Study Finds Stress Can Take Physical Toll as Badly as Junk Food

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2017). Mouse Study Finds Stress Can Take Physical Toll as Badly as Junk Food. Psych Central. Retrieved on September 22, 2018, from https://psychcentral.com/news/2017/10/17/mouse-study-finds-stress-can-take-physical-toll-as-badly-as-junk-food/127551.html

 

Scientifically Reviewed
Last updated: 17 Oct 2017
Last reviewed: By John M. Grohol, Psy.D. on 17 Oct 2017
Published on PsychCentral.com. All rights reserved.