Sensory Loss May Predict Poor Health Outcomes in Aging Adults

A new study finds that a natural decline of the five senses — vision, hearing, taste, smell, and touch — can predict a number of poor health outcomes, including reduced cognition, slower walking, greater difficulty performing everyday activities, poorer physical health, and increased risk of death.

The study began with an assessment of how sensory dysfunction, or “global sensory impairment,” a term coined by the researchers, affected physical and cognitive abilities in more than 3,000 U.S. adults aged 57-85. The findings show that adults with worse global sensory impairment moved more slowly and had greater difficulty performing daily activities.

Five years later, the same participants had even worse global sensory impairment. They moved even more slowly, were less active, and had more physical and cognitive disabilities. They also had a greater risk of dying, compared to those with lower levels of sensory impairment.

“This is the first study to show that decreased sensory function of all five senses can be a significant predictor of major health outcomes,” said Martha McClintock, Ph.D., the David Lee Shillinglaw Distinguished Service Professor of Psychology at the University of Chicago and a lead contributor to the study.

“The main mechanisms of aging could be inflammation, the lack of cellular regeneration, and/or other things. But here we show that sensory function of all five senses is depending on some common mechanism, and this mechanism is predictive of getting sick.”

The new study follows a related 2014 study by the same research team that focused solely on loss of smell as a predictor of death.

The new study, however, found “no one specific sense that is primarily responsible for this phenomenon,” said David Kern, Ph.D., coauthor of the paper and expert in sensation and perception research.

“Olfaction (smell) is certainly a big predictor, but if you take smell out of the equation, the other four senses still stand as a significant predictor of health outcomes.”

During the study, the researchers used validated tools and controlled for factors that could affect the results such as demographics, education level, drug and alcohol use and weight. They also teased apart any sensory loss that was due to environmental factors, such as exposure to loud noises that had caused poor hearing. This allowed them to measure global sensory impairment as a function of aging alone.

After the five-year follow-up, the researchers found that greater global sensory impairment was associated with the following: slower walking and less daytime activity, greater difficulty performing important daily activities, lower cognition and worse self-reported physical health, and increased risk of death.

The researchers are eager to analyze the next five-year data set of over 3,000 people, which will allow them to compare effects from five to 10 years of follow-up while trying to replicate the current findings.

If the effects are even stronger at the 10-year mark, “we can be even more confident that global sensory impairment can predict long-term decline in the health of older adults,” said Jayant Pinto, M.D., professor of surgery at the University of Chicago and study leader.

Global sensory impairment can shed light on the underlying mechanisms that drive health outcomes associated with aging. “There appears to be one or more specific physiological processes of aging — so far unidentified — that account for how the five senses decline together,” Pinto said.

The researchers point out that studies like this one could influence health policy and give physicians a valid tool to predict and treat a wide range of illnesses.

One problem, however, is that people’s sense of how good their senses are is not very good, noted McClintock.

“We are, however, moving to a point in society where you can test your senses on your own through various websites and apps,” Pinto said.

“Our group is working on an app right now to test smell. This could give people more control over their own health. Similar tests for general sensory function can move in that same direction. We can now predict how changes in our senses can influence activities we think are really important, like walking, moving, and living.”

The findings are published in the Journal of the American Geriatrics Society.

Source: University of Chicago Medical Center