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Customized Alzheimer's Prevention Plan Targets Risk Factors

Customized Alzheimer’s Prevention Plan Targets Risk Factors

With disease-modifying treatment trials for Alzheimer’s disease unsuccessful and only medications to treat symptoms available, what is next in the fight against the growing threat of AD?

James E. Galvin, M.D., M.P.H., a renowned neuroscientist at Florida Atlantic University, believes thinking “out-of-the-box” can help. Accordingly, a new program called the “Dementia Prevention Initiative” (DPI) abandons generalized methods used to research and treat AD.

Galvin is the associate dean for clinical research at FAU and a leading international expert on AD and Lewy Body Dementia (LBD), and founder of the DPI. His secret weapon: a novel “N-of-1 design” that individualizes medicine down to a single patient.

Instead of conducting a conventional trial of 100 people all getting the same treatment, he has switched it around and is conducting 100 single trials personalized to the individual. His youngest patient is 61 and the oldest is 86.

“Because Alzheimer’s disease is heterogeneous in terms of risk factors, age of onset, presentation, progression, and pathology burden, designing a study to treat individuals as a homogenous population requires thousands of patients who have to be followed for years and even decades. This approach is very costly and burdensome on clinicians and patients,” said Galvin.

The DPI is a two-year clinical trial and Galvin is developing a best-practice model of personalized care that looks at each individual as the sole unit of observation. The idea is to treat neurodegenerative diseases as a disorder that develops over a lifetime and individualize ways to build a better brain as we age. The ultimate goal is to prevent dementia from happening in the first place.

Galvin’s approach follows a form of personalized treatment similarly used in cancer and delivers an individualized prevention plan, tailored to each patient’s risk profile based on their genetic traits, biomarkers (blood, imaging, and electrophysiology), socio-demographics, lifestyle choices, and co-existent medical conditions.

This approach specifically targets the heterogeneity of AD by identifying person-specific risk factors and applying a customized intervention directed against this risk profile. Galvin anticipates that this method will provide more rapid information on whether personalized prevention plans can improve person-centered outcomes.

“While we know that a well-balanced, healthy lifestyle may be the cornerstone of disease prevention and brain health, each risk factor such as vascular, lifestyle choices, psychosocial behavior may both act independently and potentiate the effects of each other. Therefore, a prevention initiative needs to be multimodal and tailored to address individual risks,” said Galvin.

More than 16 million people in the United States and more than 60 million people worldwide are forecast to have AD by 2050 at the present pace.

In the past 25 years, only four medications to reduce the symptoms associated with AD have successfully come to market. Moreover, there is increasing evidence that multiple medical conditions increase the risk of neurodegeneration and subsequent development of dementia.

Since 2003, every symptom- and disease-modifying agent has failed in clinical trials because of challenges with safety or efficacy. This includes trials addressing a variety of mechanisms implicated in developed of AD — including the amyloid hypothesis, anti-inflammatory agents, and early-phase anti-tau therapies.

Although the single greatest risk factor for AD is age, AD is not inevitable. It is estimated that at age 85 there is a 42 percent risk of developing AD, which means that 58 percent of older adults do not develop dementia, even if amyloid can be detected in the brain.

The reasons are unknown, but may be explained in part by a host of modifiable and non-modifiable risk factors. Up to 30 percent of AD cases may be preventable through modification of risk factors and behavioral changes to mitigate the effect of those risk factors that can’t be modified.

“We know what’s good for the heart is good for the brain and we are changing people’s blood profiles, controlling blood sugars, reducing inflammation, lowering blood pressure, and changing lipids and cholesterol,” said Galvin.

“Our patients say that they are in better overall health, their moods have improved and they are more physically fit than before.”

Even if these precision approaches alone are not successful in preventing AD, Galvin believes that they may greatly improve the likelihood of amyloid- or tau-specific therapies reaching their endpoints by reducing comorbidities.

Nationally, if the onset of AD and related disorders is delayed by five years, 25 years later there would be approximately 5.7 million fewer cases, collective family savings would approach $87 billion, and societal savings would approach $367 billion.

Galvin’s article appears in the Journal of the American Geriatrics Society.

Source: Florida Atlantic University

Customized Alzheimer’s Prevention Plan Targets Risk Factors

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2017). Customized Alzheimer’s Prevention Plan Targets Risk Factors. Psych Central. Retrieved on July 18, 2018, from https://psychcentral.com/news/2017/09/26/out-of-box-thinking-to-personalize-dementia-prevention/126551.html

 

Scientifically Reviewed
Last updated: 26 Sep 2017
Last reviewed: By John M. Grohol, Psy.D. on 26 Sep 2017
Published on PsychCentral.com. All rights reserved.