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Rat Study Links Ritalin Misuse to Brain Changes Affecting Sleep, Risk-Taking

Rat Study Links Ritalin Misuse to Brain Changes Affecting Sleep, Risk-Taking

New research using rats could mean use of the stimulant drug Ritalin by people without an attention-deficit hyperactivity disorder (ADHD), may lead to changes in brain chemistry associated with risk-taking behavior, sleep disruption, and other undesirable effects.

Ritalin, the brand name for methylphenidate, is a growing problem among college students who use it without a prescription as a so-called “study enhancer.”

A central nervous system stimulant, Ritalin works by increasing the concentration of certain neurotransmitters in the brain that control reasoning, problem solving, and other behaviors.

“Although Ritalin’s effectiveness in treating ADHD is well-documented, few studies have looked at the drug’s effect on non-prescribed illicit use,” said Panayotis (Peter) Thanos, Ph.D., senior research scientist at University at Buffalo Research Institute on Addictions.

“We wanted to explore the effects of this stimulant drug on the brain, behavior, and development on non-ADHD subjects.”

Recent studies put college students’ nonprescription use of stimulant drugs (Ritalin and amphetamines such as Adderall and Dexedrine) at rates anywhere between 14 and 38 percent, depending on the type of college and age of student.

The common belief is that these drugs can help students to focus and concentrate when studying and perform better on tests. Alarmingly, these drugs are finding their way into high schools, as well, for the same reasons.

Thanos’ team, which included many University at Buffalo students he mentors, looked at changes in the brains of rats who received regular doses of methylphenidate during what would be equivalent to adolescence in humans, a time of significant brain growth and development.

“We saw changes in the brain chemistry in ways that are known to have an impact on the reward pathway, locomotor activity, and other behaviors, as well as effects on body weight,” Thanos said.

“These changes in brain chemistry were associated with serious concerns such as risk-taking behaviors, disruptions in the sleep/wake cycle and problematic weight loss, as well as resulting in increased activity and anti-anxiety and antidepressive effects.”

Further research indicated that female subjects were more sensitive to the behavioral effects of methylphenidate than the males.

Thanos hopes that studying the effects of methylphenidate on those without ADHD may lead to a greater understanding of how the drug works on the brain and behavior, and can help researchers understand the impact of the drug on young people throughout development.

“Understanding more about the effects of methylphenidate is also important as people with ADHD show greater risk to be diagnosed with a drug dependency problem,” he said.

“In addition, this study highlights the potential long-range risks college students take in using Ritalin for a quick study boost.”

Source: University of Buffalo

Rat Study Links Ritalin Misuse to Brain Changes Affecting Sleep, Risk-Taking

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Rat Study Links Ritalin Misuse to Brain Changes Affecting Sleep, Risk-Taking. Psych Central. Retrieved on December 2, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 17 May 2017)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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