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Early Depression May Indicate Genetic Risk for Additional Mental Illness

Early Depression May Indicate Genetic Risk for Additional Mental Illness

Emerging research suggests clinical features of major depressive disorder (MDD) may help identify patients with a genetic risk for major psychiatric disorders.

Researchers from the VU University Medical Center in Amsterdam, the Netherlands, discovered patients with depression at an early age, and a higher symptom severity, have an increased genetic risk for MDD, bipolar disorder, and schizophrenia.

The findings are reported in Biological Psychiatry.

The findings highlight genetic similarities between subgroups of MDD patients based on their clinical characteristics. Although researchers know that genetics play a role in the development of MDD, the complex nature of MDD patients has hindered the search for risk genes.

The new findings suggest a way to stratify the wide range of patients with MDD, which may boost the likelihood of identifying culpable genes.

“This is of importance as it suggests that it is useful to create phenotypically more homogenous groups of depressed patients when searching for genes associated with MDD,” said co-first author Dr. Judith Verduijn.

Verdulin, Brenda Penninx, Ph.D., and Dr. Yuri Milaneschi, analyzed genome-wide data of 3331 people, 1539 of whom were diagnosed with MDD, from the Netherlands Study of Depression and Anxiety.

For each patient, they calculated genomic risk profile scores for MDD, bipolar disorder, and schizophrenia.

Only characteristics associated with a more severe form of depression, including an early age at onset, high symptom severity score, and a high number of specific symptoms, were associated with higher genetic load for the three psychiatric disorders.

The analysis did not reveal any associations between genetic risk profile scores and duration of symptoms, family history of depression, recurring MDD episodes, or stage of MDD.

“This study supports the idea that psychiatric disorders are heterogeneous and that the early onset and more severe forms of depression are the ones with greater heritability,” said Dr. John Krystal, editor of Biological Psychiatry.

Source: Elsevier

Early Depression May Indicate Genetic Risk for Additional Mental Illness

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Early Depression May Indicate Genetic Risk for Additional Mental Illness. Psych Central. Retrieved on December 2, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 8 Feb 2017)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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