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Brains in Overdrive for Those Bothered Most by Noises

For Those Irked By Specific Noises, A Brain in Overdrive

People who find the sounds of chewing or breathing unbearable have changes in their brain activity, according to a new study.

A team of researchers, led by scientists at Newcastle University, report new findings of the physical basis for people suffering from a condition called misophonia, a disorder where they have a hatred of sounds such as eating, chewing, or repeated pen clicking. Called “trigger sounds” by the misophonia community, the response can be an immediate and intense fight-or-flight feeling, researchers explained.

Publishing in Current Biology, the new study shows the first evidence of clear changes in the structure of the brain’s frontal lobe in misophonia sufferers and also reports changes in brain activity.

Brain imaging revealed that people with misophonia have an abnormality in the emotional control mechanism that causes their brains to go into overdrive on hearing trigger sounds, according to the scientists.

Researchers also found brain activity originated from a different connectivity pattern to the frontal lobe. This is normally responsible for suppressing the abnormal reaction to sounds.

The researchers also found that trigger sounds evoked a heightened physiological response with increased heart rate and sweating in people with misophonia.

“For many people with misophonia, this will come as welcome news as, for the first time, we have demonstrated a difference in brain structure and function in sufferers,” said Dr. Sukhbinder Kumar from the Institute of Neuroscience at Newcastle University and the Wellcome Centre for NeuroImaging at University College London (UCL), who led the research.

“Patients with misophonia had strikingly similar clinical features and yet the syndrome is not recognized in any of the current clinical diagnostic schemes. This study demonstrates the critical brain changes as further evidence to convince a skeptical medical community that this is a genuine disorder.”

Using brain scans carried out with magnetic resonance imaging (MRI), the research team revealed a physical difference in the frontal lobe between the cerebral hemispheres of people with misophonia, with higher myelination in the grey matter of the ventromedial prefrontal cortex (vmPFC).

The study also used functional MRI to measure the brain activity of people with and without misophonia while they were listening to a range of sounds such as:

  • rain, busy café, a kettle boiling — neutral sounds;
  • baby crying, a person screaming — unpleasant sounds;
  • the sounds of breathing, eating — trigger sounds.

They found abnormal connections between this frontal-lobe area and an area called the anterior insular cortex (AIC). This area is in the grey matter of the brain, but buried in a deep fold at the side of the brain, and is known to be involved in processing emotions and integrating signals both from the body and outside world, the scientists explained.

When presented with trigger sounds, activity goes up in both areas in misophonic subjects, while in normal subjects the activity goes up in the AIC, but down in the frontal area.

The researchers said they think that this reflects an abnormality of a control mechanism between the frontal lobe and AIC.

“I hope this will reassure sufferers,” said Dr. Tim Griffiths, a professor of cognitive neurology at Newcastle University and UCL. “I was part of the skeptical community myself until we saw patients in the clinic and understood how strikingly similar the features are.

“We now have evidence to establish the basis for the disorder through the differences in brain control mechanism in misophonia,” he continued. “This will suggest therapeutic manipulations and encourage a search for similar mechanisms in other conditions associated with abnormal emotional reactions.”

Kumar adds the research opens up future possibilities for therapy.

“My hope is to identify the brain signature of the trigger sounds,” he said. “Those signatures can be used for treatment, such as for neurofeedback for example, where people can self-regulate their reactions by looking at what kind of brain activity is being produced.”

Source: Newcastle University

For Those Irked By Specific Noises, A Brain in Overdrive

Janice Wood

Janice Wood is a long-time writer and editor who began working at a daily newspaper before graduating from college. She has worked at a variety of newspapers, magazines and websites, covering everything from aviation to finance to healthcare.

APA Reference
Wood, J. (2018). For Those Irked By Specific Noises, A Brain in Overdrive. Psych Central. Retrieved on September 26, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 4 Feb 2017)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
Published on Psych All rights reserved.