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Brains of Premature Babies Not Shaped by Expectations

Preemies’ Brain Processing May Set Stage for Later Delays

Babies born prematurely don’t use their expectations about the world to shape their brains as babies born at full term do, according to new research.

The findings offer clues as to why otherwise healthy babies born prematurely face a higher risk of developmental delays as they grow, according to researchers at Princeton University, the University of Rochester Medical Center, and the University of Rochester.

In six month-old babies born at full-term, the portions of the brain responsible for visual processing respond not just to what the baby sees, but also to what the baby expects to see. That’s a sign babies are learning from their experiences, said Dr. Lauren Emberson, an assistant professor of psychology at Princeton.

But babies born prematurely don’t demonstrate that type of brain response to expectations, known as top-down processing, she noted.

“This helps bring together the picture that this type of processing is important for neural development,” Emberson said. “This also gives us insights into what might be going wrong in the case of prematurity. We believe this inability for learning to shape the brain is possibly one of the reasons.”

The researchers tested 100 babies, split between those born at full term and those born prematurely. The babies were tested at six months of age, based on their conception.

The babies were exposed to a pattern that included a sound, like a honk from a clown horn or a rattle, followed by an image of a red cartoon smiley face. The researchers used functional near-infrared spectroscopy, a technology that measures oxygenation in regions of the brain using light, to assess the babies’ brain activity.

After exposing the infants to the sound-and-image pattern, the researchers would omit the image sometimes. In the full-term infants, brain activity was detected in the visual areas of the brain, even when the image didn’t appear as expected, a sign of this top-down sensory prediction, according to the study‚Äôs findings. The brains of premature babies didn’t show this activity.

The research sets the stage for continued work to understand how top-down processing helps babies learn better and how the lack of top-down processing relates to later developmental delays in the babies born prematurely, according to Emberson. For example, the first sign of a developmental delay for a child might come when they aren’t using any words at age two, she said.

“Developmental sciences knows these missed milestones don’t happen in the moment. They’re happening in the months and years leading up to that,” Emberson said. “By looking much earlier and being able to show that there are these differences in how learning is shaping the brain, maybe we can know much sooner which babies are likely to have problems.”

The study was published in the journal Current Biology.

Source: Princeton University

Preemies’ Brain Processing May Set Stage for Later Delays

Janice Wood

Janice Wood is a long-time writer and editor who began working at a daily newspaper before graduating from college. She has worked at a variety of newspapers, magazines and websites, covering everything from aviation to finance to healthcare.

APA Reference
Wood, J. (2018). Preemies’ Brain Processing May Set Stage for Later Delays. Psych Central. Retrieved on September 26, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 29 Jan 2017)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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