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Long-Term Sleep Deprivation Suppresses Nervous System

Long-Term Sleep Deprivation Suppresses Immune System

New research discovers the reason people may get sick when they do not get enough sleep.

Investigators drew blood samples from 11 pairs of identical twins with different sleep patterns. From this they discovered that the twin with shorter sleep duration had a depressed immune system, compared with his or her sibling.

“What we show is that the immune system functions best when it gets enough sleep. Seven or more hours of sleep is recommended for optimal health,” said lead author Dr. Nathaniel Watson, co-director of the University of Washington Medicine Sleep Center.

Investigators explain that a unique feature of the research was the ability to study identical twins in order to control for the large genetic determinant to humans’ sleep duration.

Interestingly, researchers say genetics account for 31 to 55 percent of sleep durations while behavior and environment account for the remainder.

The findings appear in the journal Sleep.

Dr. Sina Gharib, the paper’s senior author, explained that a lot of existing data shows that curtailing sleep — for a limited time in the laboratory setting — can increase inflammatory markers and activate immune cells.

Little is known, though, about the effects of longstanding short sleep duration under natural conditions.

This study employed “real world” conditions, he said, and showed for the first time that chronic short sleep shuts down programs involved in immune response of circulating white blood cells.

“The results are consistent with studies that show when sleep deprived people are given a vaccine, there is a lower antibody response and if you expose sleep deprived people to a rhinovirus they are more likely to get the virus,” Watson said.

“This study provides further evidence of sleep to overall health and well-being particularly to immune health. 

The researchers, citing data from the Centers for Disease Control, said that over the past century people in the United States are sleeping an estimated 1.5 to two hours less, and about one-third of the working population sleeps less than six hours per night.

“Modern society, with its control of light, omnipresent technology, and countless competing interests for time, along with the zeitgeist de-emphasizing sleep’s importance, has resulted in the widespread deprioritization of sleep,” they wrote.

Source: University of Washington

Long-Term Sleep Deprivation Suppresses Immune System

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Long-Term Sleep Deprivation Suppresses Immune System. Psych Central. Retrieved on September 26, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 27 Jan 2017)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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