Research Suggest Multiple Paths to Autism

A new study challenges the long-held believe that alterations in social brain networks influence the development of autism. The new research posits that brain variations in infants at risk for autism may be widespread and affect multiple systems.

Autism is diagnosed based on impairments in social and communication behaviors. These symptoms tend to emerge in the second year of life. Research over the past decade has focused on identifying autistic abnormalities in early infancy.

Experts believe improved knowledge of how autism develops could potentially allow clinicians to predict the disorder before it emerges.

Attempts to identify precursors have primarily focused on social behaviors, based on the assumption that abnormalities in social brain networks arise early in life and compound throughout development.

Now, Dr. Mayada Elsabbagh from McGill University in Canada, and Dr. Mark Johnson, from Birkbeck, University of London, believe recent studies fail to support the idea of a singular pathway in the development of autism.

As published in the journal Biological Psychiatry, Elsabbagh and Johnson reviewed studies examining infants at risk for autism. They discovered behavioral research supporting evidence for general abnormalities during the first year of life.

These include delayed motor maturation, higher level of perceptual sensitivity, and poor attention flexibility. The authors also highlight brain imaging studies that provide evidence for widespread alterations throughout brain networks, rather than focal deficits in social networks.

The behavioral and imaging studies challenge the assumption of early social network abnormalities that persist throughout development and lead to emergence of the disorder.

“Our review reveals little support for localized deficits in social brain network systems within the first year of life,” said Elsabbagh.

“It instead favors the view that atypical development involving perceptual, attentional, motor, and social systems precede emerging autism and lead to overt behavioral symptoms by the second year.”

The review suggests that focusing on a single deficit may not be sufficient to identify early warning signs and will likely adjust how researchers conceptualize the disorder.

“There has been a concerted effort to identify the final common neural pathways underlying symptoms and deficits for psychiatric disorders,” said Dr. John Krystal, Editor of Biological Psychiatry.

“Yet the perspective shared by Elsabbagh and Johnson suggests that there are widespread disturbances in brain development in autism spectrum disorder and that the prominent social deficits either reflect the fact that circuits underlying social behaviors are among the many circuits affected or that some functional deficits are emergent properties of multiple affected circuits.”

Source: Elsevier