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Prenatal Oxytocin Can Predict Risk of Postpartum Depression

Prenatal Oxytocin Can Predict Risk of Postpartum Depression

A new Northwestern University study could significantly improve care for postpartum depression, researchers said.

Investigators discovered higher oxytocin levels in the third trimester of pregnancy predicts the severity of postpartum depression symptoms in women with a history of depression.

The small study of 66 women indicates the potential for finding biomarkers to predict depressive symptoms postpartum.

“It’s not ready to become a new blood test yet,” stressed lead investigator Dr. Suena Massey, a Northwestern Medicine psychiatrist.

“But it tells us that we are on the track to identifying biomarkers to help predict postpartum depression.”

The link between depressive symptoms and higher level of oxytocin surprised Massey. She had expected it to be associated with lower oxytocin.

“There’s emerging research that a past history of depression can change the oxytocin receptor in such a way that it becomes less efficient,” Massey said.

“Perhaps, when women are starting to experience early signs of depression, their bodies release more oxytocin to combat it.”

Researchers believe the findings may lead to a new range of care:

  • higher oxytocin in pregnancy increase risk of depression symptoms postpartum;
  • depression biomarkers should be screened in pregnancy, just like gestational diabetes;
  • preventive treatment could begin in pregnancy.

The research appears in the Archives of Women’s Mental Health.

Sixty-six pregnant healthy women who were not depressed were recruited for the study. Researchers measured oxytocin levels in the third trimester and depression symptoms six weeks postpartum.

Of that group, 13 of the women had a prior history of depression before the pregnancy. Among these women, the higher their oxytocin levels, the more depressive symptoms they experienced at six weeks.

Symptoms included waking up too early in the morning and not being able to get back to sleep, more worrying or anxiety, more aches and pains, headaches, changes in bowel patterns, feeling tired or a sense of heaviness, changes in appetite and feeling sad.

Oxytocin is a well-known hormone that has many functions in the body including delivery and lactation, social bonding, mother-child bonding, and stress management.

The finding is important because it shows a biological link to postpartum sadness.

Many mothers with postpartum depression feel that they are failing, Massey said, because they believe they should be happy.

“This decreases the likelihood that they will seek or accept help,” Massey said. “If we can identify the women during pregnancy who are destined to develop postpartum depression, we can begin preventive treatment.”

Obstetricians routinely screen for non-psychiatric complications of childbearing such as gestational diabetes, using readily available biomarkers. The same should be true for pregnancy-related depression, Massey said.

“In light of the far reaching consequences of untreated postpartum depression to women and their children, the ability to predict which individuals are at greatest risk for developing it yields the exciting possibility for prevention,” Massey said.

Source: Northwestern University/EurekAlert

Prenatal Oxytocin Can Predict Risk of Postpartum Depression

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Prenatal Oxytocin Can Predict Risk of Postpartum Depression. Psych Central. Retrieved on September 26, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 24 Mar 2016)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
Published on Psych All rights reserved.