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Anorexia Tied to Brain Area Linked with Habit, Addiction

Researchers at Columbia University Medical Center, New York State Psychiatric Institute, the Mortimer B. Zuckerman Mind Brain Behavior Institute, and New York University found that when people with anorexia nervosa decide what to eat, they engage a part of the brain associated with habitual behavior and addiction.

The finding appears in the journal Nature Neuroscience.

Anorexia nervosa is a serious and puzzling illness. Even as its clinical signs have become increasingly recognized, the mortality rate remains among the highest of any psychiatric disorder.

A highly stereotyped feature of this illness is the persistent selection of low-calorie, low-fat food, despite the individual’s desire for change. The brain mechanisms underlying this persistent and restrictive eating disorder are unclear.

In the current study, researchers used functional magnetic resonance imaging — which tracks activity in the brain in real time — to monitor 21 women with anorexia nervosa and 21 healthy individuals while they made a series of choices about what food to eat.

As expected, individuals with anorexia nervosa consistently chose fewer high-fat foods. Moreover, the brain regions they used to make those choices were also different. That is, for individuals with anorexia nervosa, choices about what to eat were associated with activation in the dorsal striatum, a brain region known to be related to habitual control of actions.

Furthermore, activation in fronto-striatal brain circuits during the experiment predicted how many calories they chose to consume in a meal the following day.

These findings are the first objective data to link abnormalities in brain activity with the characteristic restrictive food choice of anorexics.

Investigators believe the knowledge will open up entirely new avenues for treatment development and understanding of disease mechanisms.

“We are already developing a new psychotherapy intervention built on principles of habit reversal that helps patients with anorexia nervosa change maladaptive behaviors,” said Joanna Steinglass, M.D., one of the lead authors and associate professor of clinical psychiatry at Columbia University Medical Center.

“As we improve our understanding of brain mechanisms, new medication targets may emerge as well.”

“This study may also help link anorexia nervosa to disorders like substance abuse, gambling, and other conditions that may involve choices related to excessive activity in the dorsal striatum,” added Daphna Shohamy, Ph.D., author and associate professor of psychology and principal investigator at Columbia.

“There is tremendous value in studying how the brain makes decisions in both health and disease. Understanding how common brain circuits for decision-making contribute to seemingly unrelated disorders will allow researchers to focus on core disturbances and leverage treatment advances across different disorders.”

Source: Zuckerman Mind Brain Behavior Institute/EurekAlert

Anorexia Tied to Brain Area Linked with Habit, Addiction

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Anorexia Tied to Brain Area Linked with Habit, Addiction. Psych Central. Retrieved on September 25, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 13 Oct 2015)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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