New research has found that people with anorexia nervosa have very different microbial communities residing inside their guts, as compared to healthy individuals.
Investigators theorize that this bacterial imbalance is associated with some of the psychological symptoms related to the eating disorder.
University of North Carolina (UNC) School of Medicine researchers found evidence that the abundance and diversity of the gut microbiota — the trillions of bacteria that affect digestive health and immunity — could also affect the so-called “gut-brain axis.”
Their findings appear in the journal Psychosomatic Medicine.
The imbalance of gut bacteria could play a prominent role in the debilitating symptoms of anorexia nervosa, say the scientists. Anorexia nervosa is a serious eating disorder affects more than three million Americans and has the highest mortality rate of any psychological disorder.
“Other studies have linked gut bacteria to weight regulation and behavior,” said Ian Carroll, Ph.D., senior author of the paper and assistant professor of medicine in the UNC Center for Gastrointestinal Biology and Disease.
“Since people with anorexia nervosa exhibit extreme weight dysregulation, we decided to study this relationship further.”
Carroll added, “We’re not able to say a gut bacterial imbalance causes the symptoms of anorexia nervosa, including associated symptoms, such as anxiety and depression. But the severe limitation of nutritional intake at the center of anorexia nervosa could change the composition of the gut microbial community.
“These changes could contribute to the anxiety, depression, and further weight loss of people with the disorder. It’s a vicious cycle, and we want to see if we can help patients avoid or reverse that phenomenon. We want to know if altering their gut microbiota could help them with weight maintenance and mood stabilization over time.”
For this study, Carroll’s team collected fecal samples from 16 women with anorexia nervosa after they were first admitted into the UNC Center of Excellence for Eating Disorders and then again after their weight was restored — when they were discharged from UNC.
Then Susan Kleiman, a graduate student in Carroll’s lab and first author of the paper, characterized the composition and diversity of the gut microbiota in each sample.
Kleiman found significant changes in the gut bacteria populations between admission and discharge. The samples taken at clinic admission had fewer different types of bacteria, making the intestinal communities much less diverse.
Microbial diversity is a sign of better overall health. Upon hospital discharge, the microbial diversity had increased, but was still significantly less diverse than that of 12 healthy individuals, whose gut microbiotas were analyzed for this study.
As the microbial communities in patients with anorexia improved during clinical care and weight gain, the moods of patients also improved. Thus, the researchers noted an association between the gut microbiota and a central symptom of people with anorexia nervosa.
The question remains whether improving microbial abundance and diversity could help relieve symptoms related to the eating disorder. To find out, Carroll formed a team of researchers to further study the relationship between the gut microbiota and anorexia nervosa.
This month, the team received a five-year, $2.5-million grant from the National Institutes of Mental Health.
“Over the past 10 years, prominent researchers have learned that when you take gut microbial communities of an obese person and put it in germ-free mice — which are maintained in sterile conditions and lack intestinal microbiota – the mice gain more weight than germ-free mice that have been colonized with a gut microbiota from a lean individual,” Carroll said. “This suggests that gut microbes mediate weight gain or loss.”
Other animal studies showed that adding gut bacteria to previously germ-free mice altered their behavior, especially in relation to anxiety and stress.
“We’re not saying that altering gut bacteria will be the magic bullet for people with anorexia nervosa,” Carroll said. “Other important factors are at play, obviously. But the gut microbiota is clearly important for a variety of health and brain-related issues in humans. And it could be important for people with anorexia nervosa.”
The research is salient because currently available treatments for anorexia nervosa are suboptimal, say the researchers.
“In addition, the process of weight gain and renourishment can be extremely uncomfortable for patients. Often, patients are discharged from the hospital, and within months and sometimes weeks they find themselves losing weight again and facing readmission.
If specific alterations in their microbiota could make renourishment less uncomfortable, help patients regulate their weight, and positively affect behavior, then we might see fewer readmissions and more cures.”