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Brain Imaging Helps to Map the Way We Think

The human brain is an extremely complicated organ with many secrets. To improve understanding of how the brain makes and controls thoughts, researchers have converted structural brain imaging systems into “wiring diagrams” of connections between brain regions.

Three researchers from University of California Santa Barbara Department of Psychological & Brain Sciences (UCSB) — Michael Miller, Scott Grafton, and Matt Cieslak — used the structure of neural networks to learn the basic rules that govern which parts of the brain are most able to exert cognitive control over thoughts and actions.

This study is the first to provide a mechanistic explanation for how the frontal cortex exerts control over the trillions of individual neurons that allow people to stay focused on one task or switch to a radically different one.

The findings appear in the journal Nature Communications.

“Particular regions of your brain are predisposed to control your thoughts based on where they lie in relation to other regions,” said Miller, a UCSB psychology professor and co-author of the paper.

“The regions on the ‘outskirts’ can perform a very specific kind of control. They can move the system to distant states, like switching from working at your job to playing with your kids.”

This new research blends cutting-edge neuroscience with the emerging field of network science, which is often used to study social systems.

By applying control theory — a field traditionally used to study electrical and mechanical systems — the investigators show that being on the outskirts of the brain is necessary for the frontal cortex to dynamically control the direction of thoughts and goal-directed behavior.

“We need a basic theory of how the brain controls itself, and to get there, we suggest treating the brain as an engineering system,” said senior author Danielle Bassett, an Assistant Professor of Innovation at the University of Pennsylvania School of Engineering and Applied Science.

“Cognitive control is a lot like engineering control: You model the system’s dynamics by identifying key points; if I push on that one piece or pull this lever, I can offer a prediction of how it’s going to affect other parts of the network.”

By applying control theory equations to the wiring diagrams generated from brain scans, the researchers showed that the geographical and functional differences between regions of the brain are linked.

While the analysis cannot say whether the frontal cortex’s location or its role evolved first, it suggests that part of the frontal cortex’s ability to control executive function depends on its distance from other parts of the brain network.

“This study heralds a new wave of network science, grounded in rigorous control theory,” said co-author Grafton, director of UCSB’s Brain Imaging Center.

“When applied to state-of-the-art brain imaging data we begin to see some of the design tradeoffs inherent in the architecture of brain connections.”

Regions that are most interconnected — and therefore more internal to the network — are very good at moving the brain into nearby states — for example, from writing someone an email to speaking with that person on the phone.

“What’s particularly interesting if we look at where those inner nodes are, they’re all in ‘default mode’ regions, which are the regions that are active when you’re resting,” said Bassett. “This makes sense, because if you were engineering an optimal system, you would want to put its baseline where it can get to most of the places it has to go pretty easily.”

According to co-author Cieslak, this type of holistic understanding of the relationship between brain regions’ locations and their roles is necessary for tailoring better treatments for people who have lost executive function due to disease or injury.

Cieslak believes this fundamental understanding of how the brain controls its activity could help lead to better interventions for medical conditions associated with reduced cognitive control, such as autism, schizophrenia or dementia.

Source: University of California, Santa Barbara/EurekAlert

Brain Imaging Helps to Map the Way We Think

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Brain Imaging Helps to Map the Way We Think. Psych Central. Retrieved on September 27, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 2 Oct 2015)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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