Genetic Flaw Influences PTSD Severity

A chemical change in a particular gene appears to influence brain development in such a way as to lessen the ability to deal with strong emotions or cope with stressful experiences.

The new research is the first to show that the SKA2 gene plays a role in the development of post-traumatic stress disorder (PTSD).

The gene aberration caused by chemical imbalances appears to cause a thinner cortex in key regions of the brain decreasing brain health and influencing severe PTSD symptoms.

The findings from investigators at Boston University School of Medicine (BUSM), the National Center for PTSD and the Translational Research Center for TBI and Stress Disorders at VA Boston Healthcare System are discussed online in the journal Molecular Psychiatry.

PTSD is prevalent among veterans. Eleven to 20 percent of veterans who served in Operations Iraqi Freedom and Enduring Freedom have experienced PTSD in a given year. Studies suggest that war zone trauma, PTSD symptoms, and other post-deployment mental health problems put veterans at heightened risk for suicide relative to the general population.

The researchers performed MRI brain scans and collected blood samples from 200 veterans returning from the recent conflicts in Iraq and Afghanistan. They looked at whether a chemical change (methylation) in the function of the SKA2 gene measured in blood predicted the thickness of brain cortex (a measure of neuronal health) and psychological symptoms, specifically PTSD and depression.

“Our findings showed that an in increase in methylation of the SKA2 gene is associated with decreased cortical thickness in the prefrontal cortex, which may play a role in the development of PTSD and may explain why this gene predicts risk for mental health problems, like PTSD and suicide,” said lead and corresponding author Naomi Samimi Sadeh, Ph.D., assistant professor of psychiatry at BUSM and a psychologist in the National Center for PTSD at VA Boston.

According to the researchers the implications of this study are significant since it is difficult to predict who will develop PTSD following traumatic events.

“These findings suggest that in the future it may be possible to use a genetic blood test to identify military personnel at risk for developing PTSD in response to warzone stressors.

“We hope these findings will ultimately enhance our ability to identify individuals who are at risk for this disorder by using information about biology to improve diagnosis,” Sadeh concluded.

Source: Boston University Medical Center/EurekAlert