Potential Explanation for Link between Diabetes and Alzheimer’s
Researchers have observed that certain patients with type II diabetes (T2D) have a higher risk of developing Alzheimer’s disease (AD).
A new study discovers some individuals may have specific genetic risk factors that put them at higher risk for developing Alzheimer’s disease (AD).
Researchers at the Icahn School of Medicine at Mount Sinai used recent genome wide association study (GWAS) findings to investigate whether T2D and AD share common genetic etiological factors.
Giulio Maria Pasinetti, M.D., Ph.D. led the study which reviewed the potential impact of these genetic factors on the cellular and molecular mechanisms that may contribute to the development of both these diseases.
The study appears in the journal Molecular Aspects of Medicine.
GWAS look at differences at many points in the genetic code to see if, across a population, one or more variations in the code are found more often in those with a given trait (for example, high risk for a disease).
Even the smallest genetic variations, called single nucleotide polymorphisms (SNPs), can have a major impact on a trait by swapping just one of the 3.2 billion “letters” that make up the human DNA code.
One of the major long-term complications of T2D is an increased risk for developing AD.
Although previous studies strongly suggested a causative role of diabetes in the onset and progression of AD dementia, the specific mechanistic interactions connecting diabetes and AD had not been previously described.
“We identified multiple genetic differences in terms of SNPs that are associated with higher susceptibility to develop type II diabetes as well as Alzheimer’s disease,” says Dr. Pasinetti.
“Many of these SNPs are traced to genes whose anomalies are known to contribute to T2D and AD, suggesting that certain diabetic patients with these genetic differences are at high risk for developing Alzheimer’s. Our data highlights the need for further exploration of genetic susceptibility to Alzheimer’s disease in patients with T2D.”
Both condition are on the uptick. In many locations, the prevalence of T2D is approaching epidemic proportions while AD is increasing often as a result of demographic trends.
An estimated 312 million people suffer from T2D worldwide, exerting enormous burdens on individuals and on health care systems. Similarly, AD affects nearly 45 million people worldwide and is costly to both individuals and healthcare systems. There is currently no cure for either condition.
Mounting evidence suggests that AD dementia can be traced back to pathological conditions, such as T2D, that are initiated several decades before clinical AD onset.
Since T2D is one of the potentially modifiable risk factors for AD, it is critically important for scientists to uncover the genetics of this complex connection so that new therapeutic interventions may be developed and targeted to at-risk individuals with T2D prior to the onset of AD dementia.
This study will continue to support ongoing research applications to further explore genetic susceptibility in patients with T2D for developing AD.
Investigators also seek to improve the design of future novel treatments for a subpopulation of T2D subjects with genetic predisposition to AD, which could benefit T2D and reduce the risk for subsequent development of AD.
Outcomes from these studies identifying cellular abnormalities common to both T2D and AD can lead to the development of T2D therapies that may also help prevent subsequent development of AD in genetically predisposed individuals.
Source: Mount Sinai Hospital/EurekAlert
Nauert PhD, R. (2018). Potential Explanation for Link between Diabetes and Alzheimer’s. Psych Central. Retrieved on September 19, 2020, from https://psychcentral.com/news/2015/07/20/potential-explanation-for-link-between-diabetes-and-alzheimers/87093.html