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Pairing of Meds Reduce Serious ADHD Disruptive Behavior

Adding Risperdone, Parent Training Can Aid in Treating Aggressive ADHD

New research supports adding risperidone (brand name Risperdal) and parental training to traditional attention-deficit hyperactivity disorder medications for kids with severe aggression.

Studies have shown that the regimen of psychotropic and stimulant medications, in addition to parental training, helps relieve childhood anxiety and reduces disruptive behavior.

The new study results confirm previous findings by researchers at Ohio State University Wexner Medical Center and three other institutions. They have showed that when children with attention-deficit/hyperactivity disorder (ADHD) and serious physical aggression were prescribed both a stimulant and an antipsychotic drug — along with teaching parents behavior management techniques — they had a reduction of aggressive and serious disruptive behavior.

The new study, by L. Eugene Arnold, M.D., and Michael Aman, Ph.D., has been published online in the Journal of Child and Adolescent Psychopharmacology (JCAP).

Risperidone was first approved by the U.S. Food and Drug Administration as an antipsychotic medication for treating schizophrenia more than 20 years ago, and its use has expanded to include symptoms of bipolar disorder and autism spectrum disorders.  It has not yet been okayed for treating aggression in ADHD.

Researchers showed the addition of risperidone to parent training and a stimulant also improves teachers’ assessments of anxiety and social avoidance.

Improvement in teacher-rated anxiety and social withdrawal also contributed to improvements in parent-rated disruptive behavior. Children who showed reduced anxiety also showed less disruptive behavior.

For the “Treatment of Severe Childhood Aggression (TOSCA) Study,” 168 children (ages 6-12) who had been diagnosed with ADHD and disruptive behavior disorder (DBD) and displayed severe physical aggression were randomly assigned to two groups.

The first group consisted of parent training plus stimulant plus placebo (Basic treatment) and the second group parent training plus stimulant plus the antipsychotic drug risperidone (Augmented treatment). All participants received only parent training plus stimulant for the first three weeks of the nine-week study.

“We wanted to see if we could expand or augment treatment by adding a second medication. So, we added a placebo for the ‘Basic group’ and added risperidone for the ‘Augmented group,’ if there was room for improvement at the end of the third week,” said Aman, also coordinating principal investigator of the multi-site study.

Teacher ratings showed a significant advantage for the “Augmented group” receiving the stimulant drug plus risperidone and parent training, compared to the “Basic group,” for symptoms of anxiety.

“Clinicians need to attend to both internal emotional and external behavioral symptoms in children presenting with aggressive symptoms. Aggression accompanied by anxiety and social avoidance may partially reflect an anxiety-driven fight-or-flight reaction, which we speculate may respond to specific anxiety treatment,” Arnold said. “This possibility deserves further exploration.”

This research was funded by the National Institute of Mental Health and was conducted by the Ohio State Nisonger Center’s Clinical Trials Program, which specializes in studies of new treatments for ADHD and autism.

In addition, two other TOSCA studies have been published online in JCAP:

  • Aman and collaborators looked for predictors and moderators of treatment outcomes in children with severe aggression, DBD and ADHD. They found that “callous and unemotional” traits and ADHD symptom severity were predictors of outcome, whereas anger and irritability symptoms, manic scores and maternal education variously influenced changes in disruptive or prosocial behavior.
  • The multi-site team surveyed 150 of the participating families and reported remarkably high levels of satisfaction with the research experience (e.g., 98 percent said they would recommend the study to other parents of children having similar difficulties). Parents enthusiastically endorsed the parent training provided.

“We strongly recommend parent training or similar psychosocial support in future trials,” Aman said.

Source: Ohio State University/EurekAlert!

Adding Risperdone, Parent Training Can Aid in Treating Aggressive ADHD

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Adding Risperdone, Parent Training Can Aid in Treating Aggressive ADHD. Psych Central. Retrieved on December 2, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 21 Apr 2015)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
Published on Psych All rights reserved.