New clinical practice guidelines recommend two specific deep brain stimulation (DBS) techniques for some patients with obsessive-compulsive disorder (OCD) who fail to respond to other treatments.
The guidelines for bilateral DBS, which were found to reduce symptoms by nearly one-third, are endorsed by the American Association of Neurological Surgeons and the Congress of Neurological Surgeons (CNS).
Dr. Clement Hamani of Toronto Western Hospital led a multispecialty expert group in a systematic review of research on the effectiveness of DBS for OCD. Hamani and colleagues were tasked with analyzing the supporting evidence and developing an initial guideline for the use of DBS for patients with OCD.
Their findings are published in the journal Neurosurgery.
Deep brain stimulation — placement of electrodes in specific areas of the brain, followed by electrical stimulation of those areas — has become an important treatment for patients with Parkinson’s disease and other movement disorders.
Although many patients with OCD respond well to medications and/or psychotherapy, 40 to 60 percent continue to experience symptoms despite treatment. Over the past decade, a growing number of reports have suggested that DBS may be an effective alternative in these “medically refractory” cases.
The review and guideline development process was sponsored by the American Society of Stereotactic and Functional Neurosurgery and the CNS. Out of more than 350 papers, the reviewers identified seven high-quality studies evaluating DBS for OCD.
Based on that evidence, they conclude that bilateral stimulation (on both sides of the brain) of two brain “targets” — areas called the subthalamic nucleus and the nucleus accumbens — can be regarded as effective treatments for OCD.
In controlled clinical trials, both techniques improved OCD symptoms by around 30 percent on a standard rating scale.
That evidence forms the basis for a clinical guideline stating that bilateral DBS is a “reasonable therapeutic option” for patients with severe OCD that does not respond to other treatments.
The guideline also notes that there is “insufficient evidence” supporting the use of any type of unilateral DBS target (one side of the brain) for OCD.
The review highlights the difficulties of studying the effectiveness of DBS for OCD; because most patients respond to medical treatment, studies of this highly specialized treatment typically include only small numbers of patients.
Hamani and coauthors believe additional research is necessary to identify the most effective brain targets and the subgroups of patients most likely to benefit.
Despite the limited evidence base, DBS therapy for OCD has been approved by the Food and Drug Administration under a humanitarian device exemption.
Hamani and coauthors note that various safeguards are in place to ensure appropriate use, and prevent overuse, of DBS for OCD.
While research continues, they believe that functional neurosurgeons should continue to work with other specialists to ensure that patients with severe, medically refractory OCD continue to have access to potentially beneficial DBS therapy.
Source: Wolters Kluwer Health