Down Syndrome Study Sheds Light on Alzheimer’s
New research suggests the quest to understand the mechanism by which Alzheimer’s disease impacts memory and cognition may be more complicated than previously understood.
University of Wisconsin researchers, including lead study author Sigan Hartley, Ph.D., and Brad Christian, Ph.D., looked at the role of the brain protein amyloid-beta in adults living with Down syndrome, a genetic condition that leaves people more susceptible to developing Alzheimer’s.
As published in the journal Brain, their findings reveal more information about the earliest stages of the neurodegenerative disease.
“Our hope is to better understand the role of this protein in memory and cognitive function,” said Hartley.
“With this information we hope to better understand the earliest stages in the development of this disease and gain information to guide prevention and treatment efforts.”
However, the findings of their study not only may help scientists better understand the condition as it impacts those living with Down syndrome, but they are also relevant to adults without the genetic syndrome.
“There are many unanswered questions about at what point amyloid-beta, together with other brain changes, begins to take a toll on memory and cognition and why certain individuals may be more resistant than others,” says Hartley.
The University of Wisconsin, Madison scientists, along with collaborators at the University of Pittsburgh, studied 63 healthy adults with Down syndrome, aged 30 to 53, who did not exhibit clinical signs of Alzheimer’s or other forms of dementia.
They found that many adults with Down syndrome had high levels of amyloid-beta protein but did not suffer the expected negative consequences of the elevated protein.
Alzheimer’s disease is the sixth leading cause of death in the U.S. People with Down syndrome are born with an extra copy of the 21st chromosome, where the gene that codes for the amyloid-β protein resides.
For the study, which was conducted over the course of two days, researchers used magnetic resonance imaging (MRI) and positron emission tomography (PET) scans to capture images of the participants’ brains.
Twenty-two of the 63 participants had elevated levels of amyloid-beta but showed no evidence of diminished memory or cognitive function when compared to those without elevated levels of the protein.
The researchers controlled for differences in age and intellectual level.
Similarly, when assessed as a continuous measure, amyloid-beta levels were not tied to differences in memory or cognitive ability, such as changes in visual and verbal memory, attention, and language.
Source: University of Wisconsin, Madison
Nauert PhD, R. (2018). Down Syndrome Study Sheds Light on Alzheimer’s. Psych Central. Retrieved on October 31, 2020, from https://psychcentral.com/news/2014/09/22/study-of-downs-syndrome-improves-understanding-of-alzheimers/75214.html