Nutrition Influences Immunity, Aging

New research suggests our diet plays a direct role in how we age.

In a pair of studies, investigators from UCL (University College London) discovered an interaction between nutrition, metabolism, immunity, and the aging process.

Experts believe the findings could aid the development of new dietary interventions that make existing immune system therapies more effective.

As we age, our immune systems decline, leading to increased incidence and severity of both infections and cancer. In addition, vaccination becomes less efficient with age.

In previous work, a group at UCL led by Arne Akbar, Ph.D., showed that aging in immune system cells known as T lymphocytes was controlled by a molecule called p38 MAPK that acts as a brake to prevent certain cellular functions.

They found that this braking action could be reversed by using a p38 MAPK inhibitor, suggesting the possibility of rejuvenating old T cells using drug treatment.

In a new study published in the journal Nature Immunology the group shows that p38 MAPK is activated by low nutrient levels, coupled with signals associated with age, or senescence, within the cell.

It has been suspected for a long time that nutrition, metabolism, and immunity are linked, and this paper provides a prototype mechanism of how nutrient and senescence signals converge to regulate the function of T lymphocytes.

The study also suggests that the function of old T lymphocytes could be reconstituted by blocking one of several molecules involved in the process.

The second paper, published in The Journal of Clinical Investigation, showed that blocking p38 MAPK boosted the fitness of cells that had shown signs of aging; improving the function of mitochondria (the cellular batteries) and enhancing their ability to divide.

Extra energy for the cell to divide was generated by the recycling of intracellular molecules, a process known as autophagy.

This highlights the existence of a common signaling pathway in old/senescent T lymphocytes that controls their immune function as well as metabolism, further underscoring the intimate association between ageing and metabolism of T lymphocytes.

Akbar said, “Our life expectancy at birth is now twice as long as it was 150 years ago and our lifespans are on the increase. Healthcare costs associated with aging are immense and there will be an increasing number of older people in our population who will have a lower quality of life due in part to immune decline.

“It is therefore essential to understand reasons why immunity decreases and whether it is possible to counteract some of these changes.”

Akbar said it remains an important question whether this knowledge can be used to enhance immunity during ageing.

“Many drug companies have already developed p38 inhibitors in attempts to treat inflammatory diseases,” he said.

“One new possibility for their use is that these compounds could be used to enhance immunity in older subjects. Another possibility is that dietary instead of drug intervention could be used to enhance immunity since metabolism and senescence are two sides of the same coin.”

Source: Biotechnology and Biological Sciences Research Council

Elderly woman with orange slice photo by shutterstock.