A new radiology study finds that brain iron levels may serve as a biomarker in the diagnosis of attention-deficit hyperactivity disorder (ADHD) and help to fine-tune diagnosis.
Psychostimulant medications such as Ritalin are among the drugs commonly used to reduce ADHD symptoms. Psychostimulants affect levels of dopamine, a neurotransmitter in the brain associated with addiction.
“Much debate and concern has emerged regarding the continual rise of ADHD diagnosis in the U.S. given that two-thirds of those diagnosed receive psychostimulant medications,” said Vitria Adisetiyo, Ph.D.
“We wanted to see if we could identify brain iron as a potential noninvasive biomarker for medication-naïve ADHD to prevent misdiagnosis.”
For the study, the research team measured brain iron levels in 22 children and adolescents with ADHD, 12 of whom had never been on medication for their condition (medication naïve), and 27 healthy control children and adolescents using a magnetic resonance imaging (MRI) technique called magnetic field correlation imaging.
No contrast agents were used, and blood iron levels in the body were measured using a blood draw.
The results showed that the 12 ADHD medication-naïve patients had significantly lower brain iron levels than the 10 ADHD patients who had been on psychostimulant medication and the 27 children and adolescents in the control group.
In contrast, ADHD patients with a history of psychostimulant medication treatment had brain iron levels comparable to controls, suggesting that brain iron may increase to normal levels with psychostimulant treatment.
“Our research suggests that iron absorption into the brain may be abnormal in ADHD given that atypical brain iron levels are found even when blood iron levels in the body are normal,” Dr. Adisetiyo said.
“We found no differences in blood iron measures between controls, medication-naïve ADHD patients, or pscyhostimulant-medicated ADHD patients.”
Magnetic field correlation imaging’s ability to noninvasively detect the low iron levels may help improve ADHD diagnosis and guide optimal treatment.
Currently, ADHD diagnosis is based only on subjective clinical interviews and questionnaires. Having a biological biomarker may help inform clinical diagnosis, particularly in borderline cases, Adisetiyo noted.
If the results can be replicated in larger studies, magnetic field correlation might have a future role in determining which patients would benefit from psychostimulants — an important consideration because the drugs can become addictive if taken inappropriately and lead to abuse of other drugs like cocaine.
“We want the public to know that progress is being made in identifying potential noninvasive biological biomarkers of ADHD which may help to prevent misdiagnosis,” Adisetiyo said.
“We are currently testing our findings in a larger cohort to confirm that measuring brain iron levels in ADHD is indeed a reliable and clinically feasible biomarker.”
The research is published online in the journal Radiology.