Study Probes Brain Regions Tied to Compulsive ActionsEmerging research suggests people with extreme cases of compulsive actions typically have fewer nerve cells in brain regions associated with keeping track of goals and rewards.

Conditions related to compulsivity include binge eating, substance abuse and obsessive compulsive disorder.

As published in the journal Molecular Psychiatry, researchers show that people who are affected by disorders of compulsivity have lower grey matter volumes in the brain regions involved in keeping track of goals and rewards.

In order to understand what happens when the decision-making processes malfunction, researchers from the University of Cambridge compared almost 150 individuals with disorders including methamphetamine dependence, obesity with binge eating, and obsessive compulsive disorder with healthy volunteers of the same age and gender.

Study participants first took part in a computerized task to test their ability to make choices aimed a receiving a reward over and above making compulsive choices.

In a second study, the researchers compared brain scans taken using magnetic resonance imaging (MRI) in healthy individuals and a subset of obese individuals with or without binge eating disorder (a subtype of obesity in which the person binge eats large amounts of food rapidly).

The researchers demonstrated that all of the disorders were connected by a shift away from goal-directed behaviors towards automatic habitual choices.

The MRI scans showed that obese subjects with binge eating disorder have lower grey matter volumes – a measure of the number of neurons – in the orbitofrontal cortex and striatum of the brain compared to those who do not binge eat; these regions are involved in keeping track of goals and rewards.

Even in healthy volunteers, lower grey matter volumes were associated with a shift towards more habitual choices.

Dr. Valerie Voon, principal investigator of the study, says: “Seemingly diverse choices – drug taking, eating quickly despite weight gain, and compulsive cleaning or checking – have an underlying common thread: rather that a person making a choice based on what they think will happen, their choice is automatic or habitual.

“Compulsive disorders can have a profoundly disabling effect of individuals. Now that we know what is going wrong with their decision-making, we can look at developing treatments, for example using psychotherapy focused on forward planning or interventions such as medication which target the shift towards habitual choices.”

Source: University of Cambridge

MRI of brain photo by shutterstock.