Evidence Fails to Support Vitamin D Supplements for Depression Although vitamin D deficiency has been found to be associated with numerous health conditions, including mood disorders and major depressive disorders, current research does not suggest vitamin D supplementation reduces or prevents depression.

In a new study, researchers performed a detailed review of clinical trials that were conducted to examine the effect of vitamin D supplementation on depression.

Investigators found that few well-conducted trials of vitamin D supplementation for depression have been published and that the majority of these show little to no effect of vitamin D on depression.

The review, by Jonathan A. Shaffer, Ph.D., assistant professor of medical sciences at Columbia University Medical Center, was published recently in the online edition of Psychosomatic Medicine.

The review found that only seven trials with a total of approximately 3200 participants compared the effect of vitamin D supplementation on depression with no vitamin D supplementation.

Nearly all of these trials were characterized by methodological limitations, and all but two involved participants without clinically significant depression at the start of the study. The overall improvement in depression across all trials was small and not clinically meaningful.

However, additional analyses of the clinical data by Dr. Schaffer hinted that vitamin D supplements may help patients with clinically significant depression, particularly when combined with traditional antidepressant medication.

New well-designed trials that test the effect of vitamin D supplements in these patients are needed to determine if there is any clinical benefit.

The authors note that supplementation with vitamin D also may be effective only for those with vitamin D deficiency. They also recommend that future studies consider how vitamin D dosing and mode of delivery contribute to its effects on depression.

“Although tempting, adding vitamin D supplements to the armamentarium of remedies for depression appears premature based on the evidence available at this time,” said Shaffer.

He hopes that the current review will guide researchers to design new trials that can answer the question more definitively.

Source: Columbia University

Vitamin D supplement photo by shutterstock.