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Active Thyroid Can Increase Risk of Depression in Elders

Active Thyroid Can Increase Risk of Depression in EldersNew research discovers that when an older individuals’ thyroid glands are more active than average, it may be a risk factor for depression.

Past research has found links between an increased risk of depression and both over- and underactive thyroid glands.

This new study, found in the Journal of Clinical Endocrinology & Metabolism (JCEM), is the first to find an association between depression and thyroid activity variations within the normal range.

To determine how active the thyroid gland was, researchers measured levels of thyroid-stimulating hormone (TSH), which is the body’s signal to the thyroid gland to release more hormones.

When TSH levels are low, this suggests the thyroid gland is active and producing plenty of thyroid hormones.

Researchers also measured levels of the actual thyroid hormones at a later point in time and confirmed these subjects had increased thyroid activity.

“We found that older individuals with thyroid activity at the high end of the normal range had a substantially increased risk of developing depression over the course of an eight-year period compared to individuals who had less thyroid activity within the normal range,” said one of the study’s authors, Marco Medici, M.D.

“This suggests that people with even minor changes in thyroid function may experience similar mental health effects as those with overt thyroid disorders, including hypothyroidism and hyperthyroidism.”

Researchers analyzed data from a group of 1,503 people with an average age of 70.

At the outset of the study, researchers measured participants’ TSH levels and gauged their depression symptoms using a questionnaire.

Participants included in the study displayed no depression symptoms at the first visit. During follow-up visits over the course of eight years, on average, researchers assessed participants for the development of depression symptoms.

The study divided participants into three groups based on their TSH levels.

Study participants with TSH levels at the low end of the normal range — signaling they had more active thyroid glands — were more likely to have depression symptoms emerge during the course of the study.

“These results provide insight into the powerful effects thyroid activity can have on emotions and mental health,” Medici said.

“This information could influence the process of diagnosing and treating depression, as well as treatments for individuals with thyroid conditions.”

Source: The Endocrine Society

Active Thyroid Can Increase Risk of Depression in Elders

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Active Thyroid Can Increase Risk of Depression in Elders. Psych Central. Retrieved on December 2, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 21 Feb 2014)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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