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In Older Adults, Sleep Problems Tied to Alzheimer’s

In Older Adults, Sleep Problems Tied to Alzheimer's A new study suggests poor sleep quality may impact Alzheimer’s disease onset and progression.

Researchers at the Johns Hopkins Bloomberg School of Public Health examined the association between sleep variables and a biomarker for Alzheimer’s disease in older adults.

They discovered reports of shorter sleep duration and poorer sleep quality were associated with a greater beta amyloid burden, a hallmark of the disease. Beta amyloid is a peptide that forms amyloid plaques, found in the brains of those suffering from Alzheimer’s.

Study findings are reported online in JAMA Neurology.

“Our study found that among older adults, reports of shorter sleep duration and poorer sleep quality were associated with higher levels of beta amyloid measured by PET scans of the brain,” said Adam Spira, PhD, lead author of the study.

“These results could have significant public health implications as Alzheimer’s disease is the most common cause of dementia, and approximately half of older adults have insomnia symptoms.”

Alzheimer’s disease is an irreversible, progressive brain disease that slowly destroys memory and thinking skills.

According to the National Institutes of Health, as many as 5.1 million Americans may have the disease, with first symptoms appearing after age 60. Previous studies have linked disturbed sleep to cognitive impairment in older people.

In a cross-sectional study of adults from the neuroimaging sub-study of the Baltimore Longitudinal Study of Aging with an average age of 76, the researchers examined the association between self-reported sleep variables and beta amyloid deposits.

Study participants reported sleep that ranged from more than seven hours to no more than five hours. Beta amyloid deposition was measured by the Pittsburgh compound B tracer and PET (positron emission tomography) scans of the brain.

Reports of shorter sleep duration and lower sleep quality were both associated with greater beta amyloid buildup.

“These findings are important in part because sleep disturbances can be treated in older people. To the degree that poor sleep promotes the development of Alzheimer’s disease, treatments for poor sleep or efforts to maintain healthy sleep patterns may help prevent or slow the progression of Alzheimer disease,” said Spira.

He added that the findings cannot demonstrate a causal link between poor sleep and Alzheimer’s disease, and that longitudinal studies with objective sleep measures are needed to further examine whether poor sleep contributes to or accelerates Alzheimer’s disease.

Source: Johns Hopkins University Bloomberg School of Public Health


Woman turning off her alarm photo by shutterstock.

In Older Adults, Sleep Problems Tied to Alzheimer’s

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). In Older Adults, Sleep Problems Tied to Alzheimer’s. Psych Central. Retrieved on November 29, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 22 Oct 2013)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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