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Biological Markers Can Help Determine Suicidality

Biological Markers Help Determine if Person is SuicidalEmerging research suggests blood pressure, blood circulation and activity in the sweat glands of the fingers can reveal if a person is suicidal.

A German-Swedish study evaluated 783 depressed inpatients in Germany for hyporeactivity — a reduced ability to react to various stimuli. A suicidal depressed person reacts differently to environmental changes, compared to a healthy person.

The result confirms previous research stating that there is a strong correlation between hyporeactivity and suicide in depressed people.

“The results are so strong that I’m astonished,” said Lars-Håkan Thorell, associate professor in experimental psychiatry at Linköping University.

“We can determine very accurately whether a person risks committing suicide, which can revolutionize suicide prevention.”

Hyporeactivity can be measured by the test person listening to a pattern of tones, while the body’s reactions are measured via sensors on the fingers.

The first time they hear a tone, virtually all people react. This is a general orientation reaction which occurs automatically. But when the tone is heard again, the reaction decreases amongst some people: the hyporeactive.

The study is published in the Journal of Psychiatric Research.

Researchers found that hyporeactivity was present in up to 97 percent of depressed patients who later committed suicide, compared to just 2 percent of the depressed patients who were not hyporeactive. But the study also shows there is no relation between the severity of depression and hyporeactivity.

Thorell pointed out that the findings indicate that some of the normal population can have this neurophysical disorder.

“Everyone who has it is not suicidal — but almost all suicidal, depressed patients have it.”

Hyporeactivity was most prevalent in the bipolar patients: of 126 patients, 80.2 percent were affected, compared to 67.3 percent of the depressed patients and 58.5 percent of those with other diagnoses.

The study also shows that people with recurrent depression run a risk of becoming hyporeactive at some later point in life.

“It was probably the case that certain nerve cells in the hippocampus are damaged by depressions and negative stress,” Thorell said.


“A depressed person has a biological inability to care about the surroundings, while a healthy person continues to react.”

Source: Linköping University

Young woman with help me sign photo by shutterstock.

Biological Markers Can Help Determine Suicidality

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Biological Markers Can Help Determine Suicidality. Psych Central. Retrieved on September 26, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 25 Sep 2013)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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