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Teen Smoking, Depression Up Risk of Postmenopausal Osteoporosis

Teen Smoking, Depression Up Risk of Postmenopausal OsteoporosisA new study finds that anxiety, depression and smoking during teenage years can lead to osteoporosis or bone fractures in later life.

Experts say that although depression, anxiety, and smoking are associated with lower bone mineral density (BMD) in adults, the factors have not previously been studied during adolescence, when more than 50 percent of bone formation occurs.

The new study is the first to look at the long-term effects of smoking and depressive symptoms among adolescent girls and the potential postmenopausal impact of osteoporosis and bone fractures.

The study is published in the Journal of Adolescent Health.

Osteoporosis is a costly health problem. Although it is primarily evident in postmenopausal women, its roots can be traced to periods of growth, including adolescence.

Experts estimate that 10 million Americans already have osteoporosis and an additional 34 million are at risk.

In 2005, there were an estimated two million fractures attributed to osteoporosis costing an estimated $19 billion. These numbers are expected to rise to three million fractures and $25.3 billion in costs each year by 2025, presenting a significant public health burden.

Several research studies have shown that adult depression is associated with osteoporosis and lower bone mineral density (BMD). Smoking also has a negative impact on bone health, with adult smokers having lower BMD compared to nonsmokers, likely increasing lifetime fracture risk by as much as 31 percent.

Depression and anxiety are not uncommon among adolescent girls and smoking and alcohol use are often initiated at this time.

Both depression and substance use often become chronic after adolescence. However, until the current study, researchers were uncertain on whether these factors affect bone accrual in adolescence.

For the study, investigators recruited 262 healthy girls between 11 and 19 years from a teen health clinic in a large children’s hospital and its surrounding community to represent typically developing adolescents and enrolled them in four age cohorts (11, 13, 15, and 17 years).

The goal was to have each age cohort reflect the number of smokers proportional to national statistics. The girls each attended three annual onsite visits. Phone interviews were conducted at three-month intervals between annual visits.

Bone accrual trajectories from ages 11 to 19 were estimated for total-body bone mineral content (TB BMC) and lumbar spine and total hip bone mineral density (BMD).

Researchers found that while smokers entered adolescence with equivalent levels of lumbar spine and total hip BMD, overall BMD accrual across adolescence was significantly lower as smoking frequency increased.

Depressive symptoms showed a slightly different pattern. Girls with higher levels of symptoms had significantly lower lumbar spine BMD consistently across adolescence. There also was no association between alcohol use or anxiety symptoms or their interactions with age on any bone measure.

“Adolescence is a crucial period of development that lays the foundation for women’s health across the lifespan,” said lead investigator Lorah D. Dorn, Ph.D. “As much bone is accrued in the two years surrounding menarche as is lost in the last four decades of life.

“To our knowledge, our study is the first to test and demonstrate that smoking behavior and depressive symptoms in girls have a negative impact on bone accrual across adolescence. It may be premature to advocate screening for BMD in adolescents with depressive symptoms or those who smoke, but our study should be replicated to determine whether greater vigilance in monitoring bone mineral status is necessary,” she said.

In a commentary, outside experts praised the clinical and public health importance of the research question and mention a number of potential biological and social factors that may have contributed to these results — such as the role of body-mass index (BMI), socioeconomic status, meal schedules, and the difficulty of identifying depressive symptoms in adolescence.

Source: Elsevier Health Sciences

Teenager smoking photo by shutterstock.

Teen Smoking, Depression Up Risk of Postmenopausal Osteoporosis

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2018). Teen Smoking, Depression Up Risk of Postmenopausal Osteoporosis. Psych Central. Retrieved on December 3, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 4 Apr 2013)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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