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Untreated Depression Linked to Less Effectiveness of Shingles Vaccine

Untreated Depression Linked to Less Effectiveness of Shingles Vaccine  A new study has found a link between untreated depression in older adults and decreased effectiveness of the herpes zoster, or shingles, vaccine.

Older adults are known to be at risk for shingles, a painful condition caused by the reactivation of the varicella-zoster virus, researchers said, noting more than 1 million new cases occur each year in the U.S. The vaccine boosts immunity to the virus and can decrease the incidence and severity of the condition.

In a two-year study, led by Dr. Michael Irwin at the University of California-Los Angeles, researchers measured the immune responses to the shingles vaccination among 40 subjects aged 60 or older with a major depressive disorder and compared their responses to similar levels in 52 control patients matched by age and gender. Measurements were taken at baseline, then at six weeks, one year, and two years after the patients received the shingles vaccine or a placebo.

Depressed patients not being treated with antidepressants had lower cell-mediated immunity to the varicella-zoster virus — and were less able to respond to the shingles vaccine — compared to patients who were not depressed or who were depressed but were receiving treatment with antidepressants, the researchers found.

The findings suggest that patients with untreated depression were “poorly protected” by the shingles vaccination, according to Irwin.

Depression treatment, on the other hand, boosted cell-mediated immunity and increased the effectiveness of the vaccine, even when the treatment did not lessen depression symptoms, the researchers found. Treating depression appeared to “normalize the immune response to the zoster vaccine” in the study, Irwin said.

Larger studies are needed to evaluate the possible relationship between untreated depression and the risk of shingles, the researchers noted, along with research to establish what mechanisms are responsible for patients’ reduced immune response.

The possible connection is potentially significant: If antidepressants increase the efficacy of the shingles vaccine in those who are depressed, such treatment may have a similar effect on the immune response of depressed patients to other vaccines, such those against influenza, the researchers postulate.

Diagnosis and treatment of depression in older adults may increase the effectiveness of the shingles vaccine and help diminish the risk of shingles, the researchers conclude.

“Efforts are also needed to identify and diagnose depressed elderly patients who might benefit from either a more potent vaccine or a multi-dose vaccination schedule,” Irwin said.

The study was published in Clinical Infectious Diseases.

Source: Infectious Diseases Society of America


Hand holding a syringe photo by shutterstock.

Untreated Depression Linked to Less Effectiveness of Shingles Vaccine

Janice Wood

Janice Wood is a long-time writer and editor who began working at a daily newspaper before graduating from college. She has worked at a variety of newspapers, magazines and websites, covering everything from aviation to finance to healthcare.

APA Reference
Wood, J. (2018). Untreated Depression Linked to Less Effectiveness of Shingles Vaccine. Psych Central. Retrieved on December 3, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 17 Feb 2013)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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