Researchers from Queen Mary, University of London, have found that cognitive behavior therapy (CBT) and graded exercise therapy (GET), as supplements to specialist medical care, increase the likelihood of recovery from CFS three-fold compared to other treatments studied.
Research results are published in the journal Psychological Medicine.
Chronic fatigue syndrome is a long-term and debilitating condition that affects around 250,000 people in the UK and at least one million Americans.
In the new study, researchers followed 640 participants with CFS who were randomized into one of four treatment groups:
- Specialist medical care (SMC) alone;
- SMC plus adaptive pacing therapy (APT);
- SMC plus cognitive behavioral therapy (CBT);
- SMC plus graded exercise therapy (GET)
Evidence for recovery was assessed one year after participants were randomly allocated to treatments.
Previous published results showed that both CBT and GET led to greater reductions in symptoms and disability than either APT or SMC.
In the current analysis, researchers have gone a step further and examined how many patients had recovered from their illness after these treatments.
Patients were classed as recovered if they no longer met several criteria for ill health which were initially used to define eligibility for the trial. These included not suffering from significant fatigue or physical disability, and no longer meeting diagnostic criteria for CFS.
Patients also had to rate themselves as being “much” or “very much better” in their overall health.
The findings showed that those who received CBT or GET, in addition to SMC, were three times more likely to meet the criteria for recovery than those receiving SMC alone or in combination with APT.
Overall 22 per cent of those who received either CBT or GET, in addition to SMC, met the criteria for recovery, compared to eight per cent after APT in addition to SMC, and seven per cent after SMC alone.
There were similar patterns of recovery however CFS was defined, including those who were diagnosed as having myalgic encephalomyelitis (ME), thought by some to be the same as CFS and by others as being different.
Peter White, Professor of Psychological Medicine at Barts and the London School of Medicine and Dentistry, part of Queen Mary, was the lead co-principal investigator of the PACE trial and co-author of the latest paper.
Lead co-principal investigator Peter White commented:
“This is good news and shows that recovery from this debilitating condition is possible for some patients. We now need to go further to understand why only a relatively small proportion of patients recover, which shows how much this condition varies between individuals; one treatment is unlikely to work for everyone.
“Some people may question the use of the term ‘recovery’, and how to define when a patient is ‘recovered’ was a key issue we faced. We focused on recovery from the current episode of the illness and used several measures of both symptoms and disability to give us the most complete picture possible. Further analysis is needed to see if recovery is sustained in the long-term.”
The other co-author of the paper, Professor Michael Sharpe, continues: “The rehabilitative treatments of CBT and GET for CFS have been controversial. This analysis of the current trial data shows that not only do they achieve improvements in the majority, but that they can also lead to recovery in a substantial minority.”
Experts are enthused with the finding that people can recover from chronic fatigue syndrome. “Healthcare professionals can now be more confident in sharing this possibility with patients, many of whom are understandably concerned about their future.”
Source: Queen Mary, University of London