Emerging research suggests National Football League (NFL) players may be at increased risk of depression as they age due to brain damage resulting from concussions.
The topic is discussed in two studies that will be presented at the American Academy of Neurology’s Annual Meeting.
Anywhere from 1.6 to 3.8 million sports concussions occur each year, according to the U.S. Centers for Disease Control and Prevention.
“While it is known that sports concussions can cause immediate disturbances in mood and thinking, few studies have investigated the long-term effects that may emerge later in life, especially those related to depression,” said study author Nyaz Didehbani, Ph.D.
Researchers say the study shows that athletes who have sustained concussions in early adulthood may be at a higher risk for developing depression as they age compared to the general population.
Accordingly, experts call for depression screening and follow-up assessment by medical professionals subsequent to a concussive experience.
Said Didehbani: “Depression is a treatable condition if the proper and necessary steps are taken.”
In the first study, researchers evaluated 34 retired NFL athletes with a history of concussion and 29 people of the same age from the general population with no concussion history. Participants were tested for depression.
Concussions were retrospectively graded based on American Academy of Neurology guidelines. The researchers examined thinking skills, mood and the physical symptoms of depression.
Researchers discovered athletes who exhibited greater symptoms on the Beck Depression Inventory scored significantly higher than the minimal range for depressive symptoms. The inventory measures symptoms related to thinking, mood and the physical signs of depression.
The retired athletes included in the study reported an average of four concussions, reinforcing the correlation between depression scores and the number of lifetime concussions.
In a second study, 26 retired NFL athletes were evaluated. Of those, five had depression and 21 did not. Diffusion tensor MRI brain scans were used to measure damage to connective white matter in the brain.
White matter contains tissue and nerve fibers that help carry signals from one part of the brain to another. Damage to white matter occurs in traumatic brain injury and also has been seen in some people with depression.
By looking at the amount of white matter damage in one area of the brain, researchers could predict which former players had depression with 100 percent sensitivity and 95 percent specificity.
“Aside from providing important insights into the nature of depression as it relates to brain damage in retired NFL athletes who have been exposed to concussive and repetitive head injuries, this study also may help us to understand the similar behavioral symptoms seen in other sports-related head injuries and in combat-related blast injuries seen in armed service members,” said co-author Kyle Womack, M.D.
Source: American Academy of Neurology