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Depression, Stress Linked to Increased Risk of Stroke

Depression, Stress Linked to Increased Risk of Stroke  People over the age of 65 with high psychosocial distress, which includes depression, stress, a negative outlook and dissatisfaction with life, face an increased risk of stroke, according to a new study.

In a 10-year study, researchers followed 4,120 people in the Chicago Health and Aging Project for rates of death and stroke. Due to some participants being involved in an HMO, only 2,649 participants were analyzed for rates of stroke.

Participants were 65 years and older (average age 77, 62 percent women, 61 percent African-American). Researchers identified 151 deaths from stroke and 452 events that led to first-time hospitalization for stroke.

The researchers found that those with the most psychosocial distress had three times the risk of death from stroke and a 54 percent increased risk of first hospitalization from stroke compared to those least distressed.

The impact of psychosocial distress on stroke risk did not differ by race or by sex, researchers add.

“People should be aware that stress and negative emotions often increase with age,” said Susan Everson-Rose, Ph.D., M.P.H., study senior author and associate professor at the University of Minnesota in Minneapolis.

“Family members and caregivers need to recognize these emotions have a profound effect on health.”

In a separate analysis, researchers found an association between psychosocial distress and risk of hemorrhagic stroke (bleeding), but not ischemic stroke (caused by blood clot).

“There was about 70 percent excess risk for each unit increase in distress that wasn’t explained by known stroke risk factors,” Everson-Rose said. “So there must be other biologic pathways at play linking distress to hemorrhagic stroke in particular.”

The researchers measured psychosocial distress by four indicators: Perceived stress, life dissatisfaction, neuroticism and depressive symptoms.

They used standardized rating scales to determine the score of each indicator, such as the six-item Perceived Stress Scale. For each indicator, higher scores represent a higher level of psychosocial distress. A distress factor score was based on averaging the values of the psychosocial measures.

For the study, researchers conducted in-depth interviews in homes in three neighborhoods on the South Side of Chicago representing African-Americans and Caucasians from the same socioeconomic spectrum. The interviews covered medical history, cognitive function, socioeconomic status, behavioral patterns, traditional risk factors for stroke and psychosocial characteristics.

Stroke deaths were verified by the National Death Index and stroke hospitalizations were based on Medicare claims from the Center for Medicare and Medicaid Services.

“It’s important to pay attention when older people complain of distress and recognize that these symptoms have physical effects on health outcome and clearly affect stroke risk,” Everson-Rose said.

The study was published in the journal Stroke.

Source: American Heart Association

Depressed elderly woman photo by shutterstock.

Depression, Stress Linked to Increased Risk of Stroke

Janice Wood

Janice Wood is a long-time writer and editor who began working at a daily newspaper before graduating from college. She has worked at a variety of newspapers, magazines and websites, covering everything from aviation to finance to healthcare.

APA Reference
Wood, J. (2018). Depression, Stress Linked to Increased Risk of Stroke. Psych Central. Retrieved on December 4, 2020, from
Scientifically Reviewed
Last updated: 8 Aug 2018 (Originally: 14 Dec 2012)
Last reviewed: By a member of our scientific advisory board on 8 Aug 2018
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