Social Rejection May Induce Immune Response, Set Stage for Depression
A new study warns that stress associated with a challenge of our social standing may harm our physical or mental health in years to come.
Rejection is painful. Experiencing rejection from a boss, a friend, or a partner is difficult for many adults to handle. But for adolescents, who are dealing with the one-two punch of biological and social change, the stress associated with rejection may compromise body functions.
In a new study published in Clinical Psychological Science, researcher Michael Murphy and colleagues examine the human immune response as a potential link between social stressors like rejection and later mental and physical health outcomes.
There are many kinds of stressors that increase our risk for disease, but stressors that threaten our social standing, such as targeted rejection, seem to be particularly harmful, say the researchers.
Many people are probably familiar with targeted rejection from their school days, when a student was actively and intentionally rejected by another student or a group of students. It’s the kind of behavior that we see in so many cases of ostracism and bullying.
“Targeted rejection is central to some of life’s most distressing experiences — things like getting broken up with, getting fired, and being excluded from your peer group at school,” said Murphy. “In this study, we aimed to examine processes that may give these experiences the ability to affect health.”
Previous research has shown that people who are on the receiving end of this kind of rejection experience symptoms of depression three times faster than people who are faced with similarly severe life events.
Researchers believe that certain inflammatory processes that are part of the immune response could be a link between targeted rejection and depression.
In the study, Murphy and colleagues decided to directly investigate whether rejection-related life events affect inflammation.
To do this they followed 147 healthy adolescent women over 2.5 years. The participants did not have a personal history of mental health problems but were all at risk for major depression due to family and other personal risk factors.
The participants were assessed for psychiatric diagnoses, incidences of targeted rejection, perceived social status, expression of inflammatory signaling molecules, and indicators of low-grade inflammation every six months over the course of the study.
Researchers say the data suggests that recent exposure to targeted rejection does indeed activate the molecular signaling pathways that regulate inflammation. Participants had elevated levels of pro-inflammatory signaling molecules at visits when they had recently experienced an incidence of targeted rejection compared to visits when no targeted rejection had occurred.
Interestingly, the effect was more pronounced in those who perceived their social status to be higher.
Murphy and colleagues speculate that this inflammatory response might be adaptive for individuals at the top of a social hierarchy, giving them a survival advantage.
However, an overly productive immune response can be harmful to mental and physical health in the long run, say the researchers.
While additional studies are needed to confirm the findings, the knowledge could improve understanding of how social conditions increase risk for a variety of inflammation-related diseases, including obesity, diabetes, cardiovascular disease, certain types of cancer, and depression.
Nauert PhD, R. (2018). Social Rejection May Induce Immune Response, Set Stage for Depression. Psych Central. Retrieved on July 11, 2020, from https://psychcentral.com/news/2012/10/17/social-rejection-may-induce-immune-response-set-stage-for-depression/46187.html