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Biomarker for Autism May Be On the Horizon

Biomarker for Autism on the HorizonCurrently, physicians and medical scientists diagnose a child as possessing an autism spectrum disorders (ASD) by observing behavior patterns over the child’s first three years of life.

New research from a Swedish University suggests advanced mass spectrometry can provide a rapid, inexpensive diagnostic method for ASD.

Investigators from Uppsala University have published their study, suggesting particular protein patterns or biomarkers can be used to detect ASD, in the journal Nature Translational Psychiatry.

These would be the first acknowledged biomarkers for autism.

Many diseases are caused by protein alterations inside and outside the body’s cells. By studying protein patterns in tissue and body fluids, these alterations can be mapped to provide important information about underlying causes of disease.

Sometimes protein patterns can also be used as biomarkers to enable diagnosis or as a prognosticating tool to monitor the development of a disease. In the current study, disruptions of the nervous system were in focus when the scientists studied protein patterns in autism spectrum disorder (ASD).

Researchers performed a detailed protein analysis of blood plasma from children with ASD compared with a control group. Using advanced mass spectrometric methods, they succeeded in identifying peptides consisting of fragments of a protein whose natural function is in the immune system, the complement factor C3 protein.

The study is based on blood samples from a relatively limited group of children, but the results indicate the potential of the methodological strategy, said researcher Jonas Bergquist, Ph.D. There is already a known connection between this protein and ASD, which further reinforces the findings, he said.

The hope is that this new set of biomarkers ultimately will lead to a reliable blood-based diagnostic tool.

Source: Uppsala University

Serious child photo by shutterstock.

Biomarker for Autism May Be On the Horizon

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Biomarker for Autism May Be On the Horizon. Psych Central. Retrieved on May 23, 2018, from https://psychcentral.com/news/2012/03/26/biomarker-for-autism-may-be-on-the-horizon/36536.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.