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Antidepressant May Aid Cancer Treatment

Antidepressant May Aid Cancer TreatmentResearchers believe an antidepressant can work in combination with a class of chemical compounds that are related chemically to vitamin A to treat particular types of cancer.

The compounds, called retinoids, are already used to treat a rare subtype of acute myeloid leukemia (AML), but the drug has not been effective for the more common types of AMLs.

In the new study, team leader Arthur Zelent, Ph.D., and colleagues have been working to unlock the potential of retinoids to treat other patients with AML. As they report in a paper published in the journal Nature Medicine, they show that the key could be an antidepressant called tranylcypromine (TCP).

“Retinoids have already transformed one rare type of fatal leukemia into a curable disease. We’ve now found a way to harness these powerful drugs to treat far more common types of leukemia,” said senior author Zelent.

“Until now, it’s been a mystery why the other forms of AML don’t respond to this drug. Our study revealed that there was a molecular block that could be reversed with a second drug that is already commonly used as an antidepressant. We think this is a very promising strategy, and if these findings can be replicated in patients the potential benefits are enormous.”

ATRA works by encouraging the leukemia cells to mature and die naturally. The team thinks the failure of AML to respond to this drug may be due to genes that ATRA normally targets becoming switched off.

In their search for a drug that could be used to reboot the activity of ATRA, the team looked to an emerging area of research called epigenetics. Epigenetic drugs do not target genes directly but instead target whether genes are switched on or off.

They discovered that inhibiting an enzyme called LSD1, using TCP, could switch these genes on again and make the cancer cells susceptible to ATRA.

The team has started a Phase II clinical trial of the drug combination in acute myeloid leukemia patients.

Co-author Kevin Petrie, Ph.D, said, “Both the retinoid ATRA and the antidepressant TCP are already available in the UK and off-patent, so these drugs should not be expensive for the health service. AML remains very difficult to treat and sadly is often fatal, with rates of the disease projected to increase significantly as the population ages, so it is particularly pleasing to have identified this new treatment approach.

“Importantly, we believe these drugs are targeting only the cancer cells and leaving normal healthy cells largely untouched, so we are hopeful that they would have fewer side-effects for patients than standard drugs. We look forward to seeing the results of the clinical trials.”

Samuel Waxman, M.D., the Founder and the Scientific Director of the Samuel Waxman Cancer Research Foundation added, “This major finding is the direct result of years of collaborative research to better understand the mechanism of action using a combination therapy of drugs that are already available on the market today, which may lead to faster cures for patients.”

Source: Samuel Waxman Cancer Research Foundation

Antidepressant May Aid Cancer Treatment

Rick Nauert PhD

Rick Nauert, PhDDr. Rick Nauert has over 25 years experience in clinical, administrative and academic healthcare. He is currently an associate professor for Rocky Mountain University of Health Professionals doctoral program in health promotion and wellness. Dr. Nauert began his career as a clinical physical therapist and served as a regional manager for a publicly traded multidisciplinary rehabilitation agency for 12 years. He has masters degrees in health-fitness management and healthcare administration and a doctoral degree from The University of Texas at Austin focused on health care informatics, health administration, health education and health policy. His research efforts included the area of telehealth with a specialty in disease management.

APA Reference
Nauert PhD, R. (2015). Antidepressant May Aid Cancer Treatment. Psych Central. Retrieved on May 22, 2018, from https://psychcentral.com/news/2012/03/12/antidepressant-may-aid-cancer-treatment/35863.html

 

Scientifically Reviewed
Last updated: 6 Oct 2015
Last reviewed: By John M. Grohol, Psy.D. on 6 Oct 2015
Published on PsychCentral.com. All rights reserved.